Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HBB | P68871 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093502 | 0.71 | HTR2A (0.37) | TDP1ALOX15TSHRMAPK1CNR2 | |
| SCHEMBL27492616 | 0.69 | SIGMAR1 (0.39) | TDP1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL27396358 | 0.69 | ALDH1A1 (0.36) | ALDH1A1MAPTHPGD | |
| SCHEMBL1970316 | 0.68 | CHRNB4 (0.36) | TDP1ALDH1A1 | |
| SCHEMBL10653068 | 0.68 | KMT2A (0.41) | ALDH1A1MAPTTSHR | |
| SCHEMBL28459588 | 0.68 | ALDH1A1 (0.40) | TDP1KDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL1745011 | 0.64 | ALOX15 (0.44) | KDM4EALDH1A1MAPTHPGDALOX15 | |
| SCHEMBL14429883 | 0.64 | ALOX15 (0.44) | KDM4EALDH1A1MAPTHPGDALOX15 | |
| SCHEMBL27783710 | 0.64 | NOS3 (0.35) | KDM4EALDH1A1MAPTALOX15 | |
| SCHEMBL28981285 | 0.64 | MAPK1 (0.32) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101605777-A | Imidazoles as aldosterone synthase inhibitors | NOVARTIS AG (CH) | 2009-12-16 | — | — | CN | disclosed |