Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 2/20 | 0.44 |
| ▸ | SKP1 | P63208 | 2/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721901 | 0.84 | PTPN11 (0.46) | PTPN11CKS1BSKP1SKP2ACHE | |
| SCHEMBL4743456 | 0.78 | MAPT (0.47) | PTPN11CKS1BSKP1SKP2ACHE | |
| SCHEMBL4743444 | 0.78 | USP2 (0.54) | PTPN11CKS1BSKP1SKP2ACHE | |
| SCHEMBL4743436 | 0.76 | SMN1; SMN2 (0.48) | PTPN11CKS1BSKP1SKP2GPR119 | |
| SCHEMBL22395760 | 0.76 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL4742147 | 0.76 | LMNA (0.48) | PTPN11CKS1BSKP1SKP2ACHE | |
| SCHEMBL4739993 | 0.75 | THRB (0.54) | PTPN11CKS1BSKP1SKP2GPR119 | |
| SCHEMBL4742143 | 0.73 | ALDH1A1 (0.58) | PTPN11CKS1BSKP1SKP2KIT | |
| SCHEMBL16636900 | 0.73 | MAPK8 (0.39) | PTPN11CKS1BSKP1SKP2GPR119 | |
| SCHEMBL23727334 | 0.72 | MAPT (0.52) | CKS1BSKP1SKP2ACHEGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101959887-B | Pyrrolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC | 2013-07-31 | — | — | CN | disclosed |
| CN-101959887-A | Pyrrolopyridine as kinase inhibitor | ARRAY BIOPHARMA INC | 2011-01-26 | — | — | CN | disclosed |