Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 7/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | ILK | Q13418 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL294336 | 0.95 | AKT2 (0.59) | AKT2AKT1ILKMAPK1PIM1 | |
| SCHEMBL610112 | 0.72 | ALDH1A1 (0.33) | — | |
| SCHEMBL1570014 | 0.71 | FTO (0.42) | — | |
| SCHEMBL197153 | 0.71 | AKT2 (0.61) | AKT2AKT1ILKMAPK1PIM1 | |
| SCHEMBL82741 | 0.71 | AKT2 (1.00) | AKT2AKT1ILKPIM1ROCK2 | |
| Benzene SCHEMBL28198087 | 0.71 | AKT2 (1.00) | AKT2AKT1ILKPIM1ROCK2 | |
| SCHEMBL29253578 | 0.70 | AKT1 (0.41) | AKT2AKT1PIM1ROCK2PIM3 | |
| SCHEMBL3740850 | 0.69 | AKT2 (0.70) | AKT2AKT1ILKMAPK1PIM1 | |
| SCHEMBL3598468 | 0.69 | METAP2 (0.62) | — | |
| SCHEMBL30424015 | 0.69 | AKT2 (0.71) | AKT2AKT1ILKPIM1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102123991-A | 2-arylaminoquinazolines for the treatment of proliferative diseases | NOVARTIS AG | 2011-07-13 | — | — | CN | disclosed |
| CN-101652352-A | Quinazolines for PDK1 inhibition | NOVARTIS VACCINES & DIAGNOSTIC | 2010-02-17 | — | — | CN | disclosed |