Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.60 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28790389 | 0.80 | MET (0.66) | METKCNH2 | |
| SCHEMBL27804765 | 0.80 | MET (0.66) | METKCNH2 | |
| SCHEMBL15802804 | 0.76 | SMN1; SMN2 (0.63) | SIRT6 | |
| SCHEMBL29394339 | 0.76 | MET (1.00) | METKCNH2 | |
| SCHEMBL31013249 | 0.76 | CXCR3 (0.52) | METSIRT6 | |
| SCHEMBL27825388 | 0.74 | ALDH1A1 (0.48) | — | |
| SCHEMBL28049809 | 0.72 | ALDH1A1 (0.43) | METKCNH2 | |
| SCHEMBL2256754 | 0.72 | SIRT6 (0.52) | METSIRT6 | |
| SCHEMBL2972930 | 0.71 | SIRT6 (0.55) | METKCNH2SIRT6 | |
| SCHEMBL1265183 | 0.70 | MAPT (0.68) | SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101993416-B | Quinoline compound and preparation method thereof, medicament combination containing compound and application of compound | SHANGHAI INST MATERIA MEDICA | 2013-09-11 | — | — | CN | disclosed |
| CN-101993416-A | Quinoline compound and preparation method thereof, medicament combination containing compound and application of compound | SHANGHAI INST MATERIA MEDICA | 2011-03-30 | — | — | CN | disclosed |