SCHEMBL2780596

SCHEMBL2780596

N[C@@H](CS)C(=O)OCc1ccccc1[N+](=O)[O-]

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.47
ALDH1A1 P00352 6/20 0.45
HTT P42858 1/20 0.45
TSHR P16473 1/20 0.44
KMT2A Q03164 4/20 0.42
MEN1 O00255 3/20 0.42
HPGD P15428 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
KDM4A O75164 1/20 0.41
POLB P06746 1/20 0.40
CYP2C19 P33261 1/20 0.40
CTSD P07339 1/20 0.40
MAPT P10636 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7897984 1.00 MAOB (0.47) MAOBALDH1A1HTTTSHRKMT2A
SCHEMBL23525317 0.87 ALDH1A1 (0.49) MAOBALDH1A1HTTTSHRKMT2A
SCHEMBL1057910 0.86 KMT2A (0.51) MAOBALDH1A1HTTTSHRKMT2A
SCHEMBL7897989 0.85 ALDH1A1 (0.46) MAOBALDH1A1HTTTSHRKMT2A
SCHEMBL7897985 0.85 ALDH1A1 (0.46) MAOBALDH1A1HTTTSHRKMT2A
SCHEMBL12869704 0.84 KDM4A (0.49) MAOBALDH1A1HTTTSHRKDM4A
SCHEMBL12869702 0.84 MAOB (0.48) MAOBALDH1A1HTTTSHRKMT2A
SCHEMBL6865970 0.83 MAOB (0.52) MAOBALDH1A1HTTTSHRKMT2A
SCHEMBL7865835 0.82 KDM4A (0.47) MAOBALDH1A1HTTTSHRKDM4A
SCHEMBL28393254 0.82 KDM4A (0.47) MAOBALDH1A1HTTTSHRKDM4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090181858-A1 Adding photoregulated amino acids to the genetic code THE SCRIPPS RESEARCH INSTITUTE (US) 2009-07-16 US claimed
EP-1797177-A4 ADDING PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE SCRIPPS RESEARCH INST (US) 2008-07-09 EP claimed
EP-1797177-A2 ADDING PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE The Scripps Research Institute (US) 2007-06-20 EP claimed
US-20060134746-A1 Adding photoregulated amino acids to the genetic code THE SCRIPPS RESEARCH INSTITUTE (US) 2006-06-22 US claimed
WO-2006034410-A2 ADDING PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE THE SCRIPPS RESARCH INSTITUTE (US) 2006-03-30 WO claimed
CN-122036912-A Cytokine conjugates for the treatment of proliferative and infectious diseases 辛索克斯公司 2026-05-15 CN disclosed
US-20260115295-A1 IMMUNO ONCOLOGY COMBINATION THERAPY WITH IL-2 CONJUGATES AND ANTI-EGFR ANTIBODIES Synthorx, Inc. (US) 2026-04-30 US disclosed
EP-4725953-A1 SELF-ASSEMBLING PEPTIDES AND HYDROGELS Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2026-04-15 EP disclosed
EP-4683671-A1 CANCER THERAPY WITH IL-2 PEG CONJUGATES Synthorx, Inc. (US) 2026-01-28 EP disclosed
US-12491254-B2 Interleukin 10 conjugates and uses thereof Synthorx, Inc. (US) 2025-12-09 US disclosed
EP-4637827-A1 CANCER THERAPY WITH IL-2 CONJUGATES AND CHIMERIC ANTIGEN RECEPTOR THERAPIES Synthorx, Inc. (US) 2025-10-29 EP disclosed
US-20250325633-A1 CYTOKINE CONJUGATES FOR THE TREATMENT OF AUTOIMMUNE DISEASES Synthorx, Inc. (US) 2025-10-23 US disclosed
EP-1797177-A2 ADDING PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE The Scripps Research Institute (US) 2007-06-20 EP disclosed
WO-2006034410-A3 ADDING PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE SCRIPPS RESARCH INST (US) 2006-08-03 WO disclosed
US-20060134746-A1 Adding photoregulated amino acids to the genetic code THE SCRIPPS RESEARCH INSTITUTE (US) 2006-06-22 US disclosed
US-20060134746-A1 Adding photoregulated amino acids to the genetic code THE SCRIPPS RESEARCH INSTITUTE (US) 2006-06-22 US disclosed
WO-2006034410-A2 ADDING PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE THE SCRIPPS RESARCH INSTITUTE (US) 2006-03-30 WO disclosed
WO-2006034410-A2 ADDING PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE THE SCRIPPS RESARCH INSTITUTE (US) 2006-03-30 WO disclosed
US-6265220-B1 NON-IMMUNOCHEMICAL METHOD BY REACTING A COMPOUND COMPRISING CIS-1,4-DIOXO-2-BUTENE MOIETY OR HYDROLYTICALLY DERIVED PRECURSOR WITH HOMOCYSTEINE, THEN DETECTING PRODUCT WITHOUT SEPARATION FROM LIQUID ULLMAN EDWIN F (US) 2001-07-24 US disclosed
WO-2000000821-A1 ASSAY FOR HOMOCYSTEINE ULLMAN EDWIN F (US) 2000-01-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12491254-B2 Interleukin 10 conjugates and uses thereof IL2, CCR10, IL2RA MAOB 2819/4885ALDH1A1 294/4885HTT 2784/4885
US-20250325633-A1 CYTOKINE CONJUGATES FOR THE TREATMENT OF AUTOIMMUNE DISEASES IL2, IL2RA, IL15 MAOB 2683/4885ALDH1A1 642/4885HTT 1604/4885
US-20060134746-A1 Adding photoregulated amino acids to the genetic code NSUN3, OSGEP, AARS1 MAOB 381/4885ALDH1A1 2993/4885HTT 1247/4885
US-20260115295-A1 IMMUNO ONCOLOGY COMBINATION THERAPY WITH IL-2 CONJUGATES AND ANTI-EGFR ANTIBODIES IL2, IL2RA, EGFR MAOB 4623/4885ALDH1A1 4645/4885HTT 4066/4885
US-20090181858-A1 Adding photoregulated amino acids to the genetic code NSUN3, OSGEP, AARS1 MAOB 400/4885ALDH1A1 3004/4885HTT 1224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.