Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.58 |
| ▸ | MAOA | P21397 | 8/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23552871 | 0.88 | HTR2C (0.51) | DYRK1AMAOAACHEBCHEKDM4E | |
| SCHEMBL30939928 | 0.81 | CCNB2 (0.68) | DYRK1AMAOACCNB2CDK1CCNB1 | |
| SCHEMBL177685 | 0.81 | CCNB2 (0.68) | DYRK1AMAOACCNB2CDK1CCNB1 | |
| SCHEMBL8852871 | 0.80 | DYRK1A (0.52) | DYRK1AMAOACCNB2CDK1CCNB1 | |
| Hydrochloric Acid SCHEMBL647417 | 0.80 | CCNB2 (0.66) | DYRK1AMAOACCNB2CDK1CCNB1 | |
| SCHEMBL28471481 | 0.79 | DYRK1A (0.82) | DYRK1AMAOACCNB2CDK1CCNB1 | |
| Hydrochloric Acid SCHEMBL970432 | 0.79 | CCNB2 (0.64) | DYRK1AMAOACCNB2CDK1CCNB1 | |
| Hydrochloric Acid SCHEMBL3769079 | 0.79 | CCNB2 (0.64) | DYRK1AMAOACCNB2CDK1CCNB1 | |
| SCHEMBL16123490 | 0.78 | DYRK1A (0.53) | DYRK1AMAOACCNB2CDK1CCNB1 | |
| SCHEMBL2733976 | 0.78 | TDO2 (0.65) | DYRK1AMAOACCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927570-B2 | 1-naphthyl-or 1-dihydroacenaphthenyl-pyrido[B]indoles and uses thereof in treating cancers | BUOLAMWINI JOHN K (US) | 2015-01-06 | — | — | US | disclosed |
| US-8927570-B2 | 1-naphthyl-or 1-dihydroacenaphthenyl-pyrido[B]indoles and uses thereof in treating cancers | BUOLAMWINI JOHN K (US) | 2015-01-06 | — | — | US | disclosed |
| US-8927570-B2 | 1-naphthyl-or 1-dihydroacenaphthenyl-pyrido[B]indoles and uses thereof in treating cancers | BUOLAMWINI JOHN K (US) | 2015-01-06 | — | — | US | disclosed |
| US-20130131070-A1 | 1-Aryl or 1- Heteroaryl-Pyrido(B)indoles and Uses Thereof | BUOLAMWINI JOHN K (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130131070-A1 | 1-Aryl or 1- Heteroaryl-Pyrido(B)indoles and Uses Thereof | BUOLAMWINI JOHN K (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130131070-A1 | 1-Aryl or 1- Heteroaryl-Pyrido(B)indoles and Uses Thereof | BUOLAMWINI JOHN K (US) | 2013-05-23 | — | — | US | disclosed |
| US-8329723-B2 | 1-aryl- or 1-heteroaryl-pyrido[B]indoles and uses thereof in treating cancers | QUESREMA ENTERPRISES | 2012-12-11 | — | — | US | disclosed |
| US-8329723-B2 | 1-aryl- or 1-heteroaryl-pyrido[B]indoles and uses thereof in treating cancers | QUESREMA ENTERPRISES | 2012-12-11 | — | — | US | disclosed |
| US-8329723-B2 | 1-aryl- or 1-heteroaryl-pyrido[B]indoles and uses thereof in treating cancers | QUESREMA ENTERPRISES | 2012-12-11 | — | — | US | disclosed |
| US-20100317667-A1 | 1-aryl-or 1-heteroaryl-pyrido[B]indoles and uses thereof | QUESREMA ENTERPRISES | 2010-12-16 | — | — | US | disclosed |
| US-20100317667-A1 | 1-aryl-or 1-heteroaryl-pyrido[B]indoles and uses thereof | QUESREMA ENTERPRISES | 2010-12-16 | — | — | US | disclosed |
| US-20100317667-A1 | 1-aryl-or 1-heteroaryl-pyrido[B]indoles and uses thereof | QUESREMA ENTERPRISES | 2010-12-16 | — | — | US | disclosed |
| WO-2010123583-A2 | 1-ARYL OR 1-HETEROARYL-PYRIDO[B]INDOLES AND USES THEREOF | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317667-A1 | 1-aryl-or 1-heteroaryl-pyrido[B]indoles and uses thereof | NAT1, KMO, PKD1 | DYRK1A 932/4885MAOA 1494/4885CCNB2 384/4885 |
| US-20130131070-A1 | 1-Aryl or 1- Heteroaryl-Pyrido(B)indoles and Uses Thereof | HRH3, HRH4, CNR1 | DYRK1A 1295/4885MAOA 1249/4885CCNB2 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.