Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 8/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | GABRP | O00591 | 1/20 | 0.65 |
| ▸ | GABRD | O14764 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.65 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | MAOA | P21397 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29756407 | 1.00 | TDO2 (0.65) | TDO2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL30763468 | 0.89 | DYRK1A (0.63) | TDO2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL10631483 | 0.89 | DYRK1A (0.63) | TDO2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL30763467 | 0.89 | DYRK1A (0.63) | TDO2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL30763469 | 0.89 | DYRK1A (0.63) | TDO2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL30763470 | 0.89 | DYRK1A (0.63) | TDO2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL28812452 | 0.84 | TDO2 (0.58) | TDO2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL29045951 | 0.80 | PARP14 (0.54) | TDO2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL29045946 | 0.80 | PARP14 (0.54) | TDO2KDM4EMEN1MAPTKMT2A | |
| Harman SCHEMBL141723 | 0.79 | MAOA (1.00) | TDO2KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250333412-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI SA (FR) | 2025-10-30 | — | — | US | disclosed |
| US-12275733-B2 | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders | SANOFI (FR) | 2025-04-15 | — | — | US | disclosed |
| US-20240182469-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2024-06-06 | — | — | US | disclosed |
| US-11827633-B2 | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders | SANOFI (FR) | 2023-11-28 | — | — | US | disclosed |
| CN-110382496-B | Substituted pyrido [3,4-b ] indoles for the treatment of cartilage disorders | 赛诺菲 | 2022-08-09 | — | — | CN | disclosed |
| US-11130755-B2 | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders | SANOFI (FR) | 2021-09-28 | — | — | US | disclosed |
| EP-3792262-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2021-03-17 | — | — | EP | disclosed |
| EP-3535263-B1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI SA (FR) | 2020-09-30 | — | — | EP | disclosed |
| US-20200095242-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2020-03-26 | — | — | US | disclosed |
| US-10590158-B2 | Total synthesis of shishijimicin A and analogs thereof | WILLIAM MARSH RICE UNIVERSITY (US) | 2020-03-17 | — | — | US | disclosed |
| US-20160039845-A1 | BIS-B-CARBOLINE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | XINJIANG HUASHIDAN PHARMACEUTICAL RESEARCH CO., LTD (CN) | 2016-02-11 | — | — | US | disclosed |
| EP-2924042-A1 | BIS- -CARBOLINE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Xinjiang Huashidan Pharmaceutical Research Co., Ltd. (CN) | 2015-09-30 | — | — | EP | disclosed |
| EP-2924042-A1 | BIS- -CARBOLINE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Xinjiang Huashidan Pharmaceutical Research Co., Ltd. (CN) | 2015-09-30 | — | — | EP | disclosed |
| CN-104812761-A | Bis-beta-carboline compound and preparation method, pharmaceutical composition and use thereof | XINJIANG HUASHIDAN PHARMACEUTICAL RES CO LTD | 2015-07-29 | — | — | CN | disclosed |
| CN-104755078-A | Application of harmine derivatives in preparation of antimicrobial agents | XINJIANG HUASHIDAN PHARMACEUTICAL RES CO LTD | 2015-07-01 | — | — | CN | disclosed |
| US-20130274258-A1 | CARBAZOLE AND CARBOLINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC APPLICATIONS THEREOF | PHILIP MORRIS PRODUCTS S.A. (CH) | 2013-10-17 | — | — | US | disclosed |
| EP-2635575-A1 | CARBAZOLE AND CARBOLINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC APPLICATIONS THEREOF | Philip Morris Products S.a.s. (CH) | 2013-09-11 | — | — | EP | disclosed |
| CN-103070862-A | Application of harmine derivative in preparation of antibacterial drugs | XINJIANG HUASHIDAN PHARMACEUTICAL RES CO LTD | 2013-05-01 | — | — | CN | disclosed |
| EP-2455378-A1 | Carbazole and carboline derivatives, and preparation and therapeutic applications thereof | Philip Morris Products S.A. (CH) | 2012-05-23 | — | — | EP | disclosed |
| WO-2012059232-A1 | CARBAZOLE AND CARBOLINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC APPLICATIONS THEREOF | PHILIP MORRIS PRODUCTS S.A (CH) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039845-A1 | BIS-B-CARBOLINE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | BRCA1, CA7, DCK | TDO2 3232/4885KDM4E 3383/4885MEN1 123/4885 |
| US-10590158-B2 | Total synthesis of shishijimicin A and analogs thereof | SYK, UGT1A7, FCGRT | TDO2 2794/4885KDM4E 408/4885MEN1 3370/4885 |
| US-11827633-B2 | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders | COL2A1, IDO1, COL1A1 | TDO2 89/4885KDM4E 706/4885MEN1 3788/4885 |
| US-11130755-B2 | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders | COL2A1, IDO1, COL1A1 | TDO2 89/4885KDM4E 706/4885MEN1 3788/4885 |
| US-20130274258-A1 | CARBAZOLE AND CARBOLINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC APPLICATIONS THEREOF | CCNI, CCNY, CYCS | TDO2 1026/4885KDM4E 2711/4885MEN1 775/4885 |
| US-20200095242-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | COL2A1, IDO1, COL1A1 | TDO2 89/4885KDM4E 706/4885MEN1 3788/4885 |
| US-20240182469-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | COL2A1, IDO1, COL1A1 | TDO2 89/4885KDM4E 706/4885MEN1 3788/4885 |
| US-12275733-B2 | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders | COL2A1, IDO1, COL1A1 | TDO2 89/4885KDM4E 706/4885MEN1 3788/4885 |
| US-20250333412-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | COL2A1, IDO1, COL1A1 | TDO2 82/4885KDM4E 723/4885MEN1 3740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.