Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 2/20 | 0.38 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807992 | 0.85 | KDM4E (0.36) | LMNAALDH1A1MAPTGABRG2GABRB3 | |
| SCHEMBL27807969 | 0.83 | HRH4 (0.34) | POLBENPP1ENPP3LMNAALDH1A1 | |
| SCHEMBL27785954 | 0.83 | GABRG2 (0.42) | GABRG2GABRB3GABRA2HCRTR2 | |
| SCHEMBL27786138 | 0.83 | GABRG2 (0.42) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27785944 | 0.83 | BCL2L11 (0.33) | LMNAMAPTGABRG2GABRB3GABRA2 | |
| SCHEMBL27786008 | 0.82 | CYP11B1 (0.41) | TLR7 | |
| SCHEMBL28787429 | 0.82 | HRH4 (0.35) | POLBENPP1ENPP3ALDH1A1KMT2A | |
| SCHEMBL27807911 | 0.82 | HRH4 (0.35) | L3MBTL1LMNAALDH1A1MAPTGAA | |
| SCHEMBL28787406 | 0.82 | CD38 (0.33) | POLBL3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL2661594 | 0.78 | USP1 (0.40) | USP1WDR48POLBENPP1ENPP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |