Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18513515 | 0.86 | MEN1 (0.49) | BRD4MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL2450799 | 0.82 | L3MBTL1 (0.52) | BRD4RAB9ANPSR1MAPTSMN1; SMN2 | |
| SCHEMBL8749479 | 0.81 | PAX8 (0.47) | BRD4PAX8KAT8CREBBPMEN1 | |
| SCHEMBL10210873 | 0.80 | BRD4 (0.52) | BRD4PAX8MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL30504285 | 0.80 | BRD4 (0.62) | BRD4PAX8KAT8CREBBPMEN1 | |
| SCHEMBL3910121 | 0.79 | BRD4 (0.51) | BRD4PAX8KAT8CREBBPMEN1 | |
| SCHEMBL14065550 | 0.79 | BRD4 (0.51) | BRD4PAX8KAT8CREBBPMEN1 | |
| SCHEMBL67115 | 0.79 | BRD4 (0.51) | BRD4PAX8CREBBPMEN1KMT2A | |
| SCHEMBL30013638 | 0.79 | BRD4 (0.51) | BRD4PAX8CREBBPMEN1KMT2A | |
| SCHEMBL30455057 | 0.79 | HTR3E (0.51) | BRD4PAX8KMT2ANPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102740847-A | Heteroaryl compounds and uses thereof | AVILA THERAPEUTICS INC | 2012-10-17 | — | — | CN | disclosed |
| CN-102083800-A | Heteroaryl compounds and uses thereof | AVILA THERAPEUTICS AND USES TH | 2011-06-01 | — | — | CN | disclosed |