Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | RARB | P10826 | 5/20 | 0.50 |
| ▸ | MMP12 | P39900 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RARA | P10276 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28245804 | 0.90 | LMNA (0.58) | HDAC2HDAC1ALDH1A1MAPTKMT2A | |
| SCHEMBL27492664 | 0.86 | FDFT1 (0.57) | MMP12MMP2MMP9MMP13MMP14 | |
| Hydrogen Peroxide SCHEMBL29262757 | 0.84 | GRIN2D (0.49) | MGLLALDH1A1LMNAPKM | |
| SCHEMBL8716921 | 0.83 | HDAC2 (0.50) | HDAC2HDAC1MGLLMMP12MMP2 | |
| SCHEMBL11807780 | 0.83 | HDAC2 (0.50) | HDAC2HDAC1MGLLMMP12MMP2 | |
| SCHEMBL8716910 | 0.83 | HDAC2 (0.50) | HDAC2HDAC1MGLLMMP12MMP2 | |
| Bicarbonate SCHEMBL2016975 | 0.83 | ACHE (0.55) | MGLLALDH1A1LMNA | |
| SCHEMBL21802444 | 0.82 | SIGMAR1 (0.53) | LMNAPKM | |
| SCHEMBL1299996 | 0.82 | SIGMAR1 (0.53) | LMNAPKM | |
| SCHEMBL6569356 | 0.82 | SIGMAR1 (0.53) | LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108778766-A | Method for carrying out part dyeing to plastic part | 科思创德国股份有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-108290820-A | Method for recovering aromatic alcohol from melt polymerization and system for recovering same | 沙特基础工业全球技术有限公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-105189604-B | The production of makrolon with limited metal residue | 沙特基础全球技术有限公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-107075103-A | The method that makrolon is manufactured using liquid alcohol/ketone mixtures | 沙特基础工业全球技术有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-104231254-B | For the method producing polycarbonate compositions | 沙特基础全球技术有限公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-105473223-A | Heterogeneous catalysts for the transesterification of aromatic alcohols; and methods of making and use thereof | SABIC INNOVATIVE PLASTICS IP BV | 2016-04-06 | — | — | CN | disclosed |
| CN-103003050-B | Apparatus and method for producing products from pigment-containing polymer mixtures | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-24 | — | — | CN | disclosed |
| CN-105189604-A | Production of a polycarbonate with limited metal residuals | SABIC INNOVATIVE PLASTICS IP | 2015-12-23 | — | — | CN | disclosed |
| CN-104231254-A | Process for the manufacture of polycarbonate compositions | SABIC INNOVATIVE PLASTICS IP | 2014-12-24 | — | — | CN | disclosed |
| CN-104136508-A | Process for the production of low stress and optical quality film for use in opto-electronic devices | BAYER MATERIALSCIENCE AG | 2014-11-05 | — | — | CN | disclosed |
| CN-102224010-A | Security feature in security or value documents | BAYER MATERIALSCIENCE AG | 2011-10-19 | — | — | CN | disclosed |
| CN-102196920-A | ID card with laser engraving resistance | BAYER MATERIALSCIENCE AG | 2011-09-21 | — | — | CN | disclosed |
| CN-102164753-A | Use of plastic films in colour laser printing | BAYER MATERIALSCIENCE AG | 2011-08-24 | — | — | CN | disclosed |