Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.33 |
| ▸ | GABRE | P78334 | 2/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.33 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877183 | 0.83 | SLC22A6 (0.43) | SLC22A6TDP1FOLH1SMN1; SMN2GABRR1 | |
| SCHEMBL28006567 | 0.81 | SLC22A6 (0.38) | SLC22A6TDP1FOLH1SMN1; SMN2GABRR1 | |
| SCHEMBL499817 | 0.80 | GPR84 (0.39) | SLC22A6GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL27824024 | 0.80 | TSHR (0.38) | SLC22A6TDP1FOLH1SMN1; SMN2 | |
| SCHEMBL8668525 | 0.77 | DPP4 (0.50) | DPP4 | |
| SCHEMBL8433897 | 0.77 | GPR84 (0.46) | — | |
| SCHEMBL27464365 | 0.76 | SLC22A6 (0.38) | SLC22A6TDP1FOLH1SMN1; SMN2GABRR1 | |
| SCHEMBL6330069 | 0.76 | DPP4 (0.36) | DPP4SLC22A6GABRPGABRDGABRA1 | |
| Hydrochloric Acid SCHEMBL9624578 | 0.75 | GPR84 (0.44) | — | |
| SCHEMBL9805491 | 0.75 | GABRP (0.33) | DPP4SLC22A6GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102333777-B | Nitrogen-containing fused heterocyclic compounds and their use as beta-amyloid production inhibitors | EISAI R&D MAN CO LTD | 2014-06-25 | — | — | CN | disclosed |
| CN-102333777-A | Nitrogen-containing fused heterocyclic compounds and their use as beta-amyloid production inhibitors | EISAI R&D MAN CO LTD | 2012-01-25 | — | — | CN | disclosed |