SCHEMBL8433897

SCHEMBL8433897

CCCCC(CC(=O)O)C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 4/20 0.46
CA2 P00918 2/20 0.41
MAPK1 P28482 1/20 0.41
FDPS P14324 1/20 0.39
PDF Q9HBH1 1/20 0.39
CTSL P07711 1/20 0.38
CTSS P25774 1/20 0.38
CTSK P43235 1/20 0.38
MAPT P10636 1/20 0.38
S1PR2 O95136 1/20 0.38
S1PR1 P21453 1/20 0.38
CA1 P00915 1/20 0.37
AKR1B1 P15121 1/20 0.37
FAAH O00519 1/20 0.36
FFAR4 Q5NUL3 1/20 0.36
FFAR1 O14842 1/20 0.36
MMP1 P03956 2/20 0.36
MMP2 P08253 2/20 0.36
MMP3 P08254 2/20 0.36
MMP7 P09237 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9624578 0.98 GPR84 (0.44) GPR84CA2MAPK1FDPSPDF
SCHEMBL8433717 0.92 GPR84 (0.56) GPR84FDPSMAPTS1PR2S1PR1
SCHEMBL499817 0.88 GPR84 (0.39) GPR84MAPTS1PR2S1PR1
SCHEMBL9624573 0.82 ALDH1A1 (0.40) CA2MAPK1FDPSCTSLCTSS
SCHEMBL9624831 0.82 AKR1B1 (0.45) GPR84MAPTS1PR2S1PR1AKR1B1
SCHEMBL20222968 0.82 GPR84 (0.47) GPR84CA2MAPK1FDPSPDF
SCHEMBL20222989 0.82 GPR84 (0.47) GPR84CA2MAPK1FDPSPDF
SCHEMBL18822157 0.81 GPR84 (0.52) GPR84FDPSMAPTS1PR2S1PR1
SCHEMBL9419145 0.79 CA1 (0.42) CA2FDPSCTSLCTSSCTSK
SCHEMBL1987290 0.79 FDPS (0.41) CA2MAPK1FDPSCTSLCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5672742-A AN ALPHA,ALPHA-BIS(TRIFLUOROMETHYL)ARYLACETIC ACID ESTER IS CONVERTED TO THE CORRESPONDING CARBOXYLIC ACID SALT UNDER ACTION OF BASE AND WATER; DECARBOXYLATION; HYDROLYSIS NIPPON MEKTRON LIMITED (JP) 1997-09-30 US claimed
JP-1242543-A None JP disclosed
JP-8333303-A None JP disclosed
JP-8333358-A None JP disclosed
EP-0499221-B1 Optically active compound, liquid crystal composition, liquid crystal device, display apparatus and display method CANON KK (JP) 1999-12-08 EP disclosed
US-5808132-A α,α-bis(trifluoromethyl)arylacetic acid ester; its intermediates for synthesis; and process for producing the same NIPPON MEKTRON, LIMITED (JP) 1998-09-15 US disclosed
US-5672742-A AN ALPHA,ALPHA-BIS(TRIFLUOROMETHYL)ARYLACETIC ACID ESTER IS CONVERTED TO THE CORRESPONDING CARBOXYLIC ACID SALT UNDER ACTION OF BASE AND WATER; DECARBOXYLATION; HYDROLYSIS NIPPON MEKTRON LIMITED (JP) 1997-09-30 US disclosed
US-5672742-A AN ALPHA,ALPHA-BIS(TRIFLUOROMETHYL)ARYLACETIC ACID ESTER IS CONVERTED TO THE CORRESPONDING CARBOXYLIC ACID SALT UNDER ACTION OF BASE AND WATER; DECARBOXYLATION; HYDROLYSIS NIPPON MEKTRON LIMITED (JP) 1997-09-30 US disclosed
US-5672742-A AN ALPHA,ALPHA-BIS(TRIFLUOROMETHYL)ARYLACETIC ACID ESTER IS CONVERTED TO THE CORRESPONDING CARBOXYLIC ACID SALT UNDER ACTION OF BASE AND WATER; DECARBOXYLATION; HYDROLYSIS NIPPON MEKTRON LIMITED (JP) 1997-09-30 US disclosed
JP-H08333358-A PERFLUORO(2-METHYL-1,2-EPOXYPROPYL) ETHER COMPOUND AND ITS PRODUCTION NIPPON MEKTRON LTD 1996-12-17 JP disclosed
US-5098600-A Composites of heteroaryl liquid crystal compounds CANON KABUSHIKI KAISHA (JP) 1992-03-24 US disclosed
EP-0301511-B1 OPTICALLY ACTIVE COMPOUND AND LIQUID CRYSTAL COMPOSITION CONTAINING SAME CANON KABUSHIKI KAISHA (JP) 1992-01-22 EP disclosed
US-5073306-A Trifluoromethylalkyl substituted CANON KABUSHIKI KAISHA (JP) 1991-12-17 US disclosed
EP-0440134-A1 Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus CANON KABUSHIKI KAISHA (JP) 1991-08-07 EP disclosed
EP-0435106-A2 Liquid crystal compound, liquid crystal composite including the compound and liquid crystal device utilizing the composite CANON KABUSHIKI KAISHA (JP) 1991-07-03 EP disclosed
US-4917817-A Optical active compound, process for producing same and liquid crystal composition containing same CANON KABUSHIKI KAISHA (JP) 1990-04-17 US disclosed
US-4918213-A HAVING A TRIFLUOROMETHYL GROUP ATTACHED TO ASYMMETRIC CARBON ATOM; STABLE; OPTICAL DEVICES CANON KABUSHIKI KAISHA (JP) 1990-04-17 US disclosed
JP-H01242543-A LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL COMPOSITION AND ELEMENT CONTAINING SAID COMPOUND CANON INC 1989-09-27 JP disclosed
EP-0301511-A1 Optically active compound and liquid crystal composition containing same CANON KABUSHIKI KAISHA (JP) 1989-02-01 EP disclosed
EP-0300497-A1 Optically active compound, process for producing same and liquid crystal composition containing same CANON KABUSHIKI KAISHA (JP) 1989-01-25 EP disclosed