SCHEMBL278281

SCHEMBL278281

Cc1cccc(Sc2ccccn2)c1CC(=O)ON1C(=O)CCC1=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.39
KMT2A Q03164 2/20 0.37
MEN1 O00255 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
GAA P10253 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
TSHR P16473 1/20 0.35
EYA2 O00167 2/20 0.35
SMN1; SMN2 Q16637 4/20 0.35
KDM4E B2RXH2 2/20 0.35
MAPK1 P28482 1/20 0.35
GCK P35557 1/20 0.34
NPC1 O15118 2/20 0.33
ALDH1A1 P00352 2/20 0.33
RAB9A P51151 2/20 0.33
HPGD P15428 1/20 0.33
ALOX15 P16050 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1679369 0.91 LMNA (0.38) LMNAKMT2AMEN1CYP1A2CYP3A4
SCHEMBL4405681 0.82 GCK (0.40) LMNAKMT2AMEN1CYP1A2CYP3A4
SCHEMBL30392206 0.79 MEN1 (0.41) LMNAKMT2AMEN1CYP1A2CYP3A4
SCHEMBL28384909 0.79 MEN1 (0.41) LMNAKMT2AMEN1CYP1A2CYP3A4
SCHEMBL19209537 0.78 APOBEC3G (0.40) LMNAKMT2AMEN1GAASMN1; SMN2
SCHEMBL465750 0.75 LMNA (0.37) LMNAKMT2AMEN1SMN1; SMN2KDM4E
SCHEMBL28514925 0.75 LMNA (0.45) LMNAKMT2AMEN1SMN1; SMN2KDM4E
SCHEMBL12092095 0.72 LMNA (0.42) LMNAKMT2AMEN1SMN1; SMN2KDM4E
SCHEMBL30498662 0.72 ALDH1A1 (0.56) LMNAKMT2AMEN1SMN1; SMN2NPC1
SCHEMBL277974 0.72 ALDH1A1 (0.56) LMNAKMT2AMEN1SMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8133680-B2 affinity substrate comprises polydimethylsiloxane stamp alternately peptide-terminated or antibody terminated; WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2012-03-13 US disclosed
EP-1255996-B1 BIOCHEMICAL BLOCKING LAYER FOR LIQUID CRYSTAL ASSAY WISCONSIN ALUMNI RES FOUND (US) 2010-05-26 EP disclosed
US-7651662-B2 Rubbed substrate surfaces; activation; uniform anchoring of liquid crystals WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2010-01-26 US disclosed
EP-1668366-B1 USING LIQUID CRYSTALS TO DETECT AFFINITY MICROCONTACT PRINTED BIOMOLECULES WISCONSIN ALUMNI RES FOUND (US) 2008-01-09 EP disclosed
EP-1668366-A2 USING LIQUID CRYSTALS TO DETECT AFFINITY MICROCONTACT PRINTED BIOMOLECULES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2006-06-14 EP disclosed
US-20050260703-A1 Biochemical blocking layer for liquid crystal assay WISCONSIN ALUMNI RESEARCH FOUNDATION 2005-11-24 US disclosed
WO-2005080983-A2 USING LIQUID CRYSTALS TO DETECT AFFINITY MICROCONTACT PRINTED BIOMOLECULES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2005-09-01 WO disclosed
US-20050079486-A1 USING LIQUID CRYSTALS TO DETECT AFFINITY MICROCONTACT PRINTED BIOMOLECULES -, Wiscnsin Alumni Research Foundation (US) 2005-04-14 US disclosed
US-20040161800-A1 Biochemical blocking layer for liquid crystal assay WISCONSIN ALUMNI RESEARCH FOUNDATION 2004-08-19 US disclosed
US-6692699-B2 RUBBED SO THAT IT DRIVES UNIFORM ANCHORING OF LIQID CRYSTALS AND BONDS THE BIOMOLECULE RECOGNITION AGENT WISCONSIN ALUMNI RESEARCH FOUNDATION 2004-02-17 US disclosed
EP-1255996-A2 BIOCHEMICAL BLOCKING LAYER FOR LIQUID CRYSTAL ASSAY WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2002-11-13 EP disclosed
US-20020055093-A1 Biochemical blocking layer for liquid crystal assay NATIONAL SCIENCE FOUNDATION 2002-05-09 US disclosed
WO-2001061325-A2 BIOCHEMICAL BLOCKING LAYER FOR LIQUID CRYSTAL ASSAY WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2001-08-23 WO disclosed