Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949763 | 0.82 | SMN1; SMN2 (0.58) | HPGDALOX15HSD17B10ALDH1A1L3MBTL1 | |
| SCHEMBL948199 | 0.81 | KDM4E (0.50) | ALDH1A1L3MBTL1TDP1MAPTKDM4E | |
| SCHEMBL28048741 | 0.78 | ALDH1A1 (0.54) | HSD17B10ALDH1A1TDP1SMN1; SMN2HTT | |
| SCHEMBL9586577 | 0.78 | KDM4E (0.51) | HPGDALOX15HSD17B10ALDH1A1POLB | |
| SCHEMBL954343 | 0.78 | BCAT2 (0.47) | HSD17B10ALDH1A1L3MBTL1TDP1POLB | |
| SCHEMBL3383809 | 0.73 | KDM4E (0.46) | ALDH1A1L3MBTL1TDP1MAPTKDM4E | |
| SCHEMBL15510700 | 0.73 | KDM4E (0.40) | HSD17B10ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL957616 | 0.73 | CHRNB2 (0.53) | ALOX15ALDH1A1L3MBTL1TDP1POLB | |
| SCHEMBL28191526 | 0.72 | MAPT (0.56) | HPGDHSD17B10ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10432295 | 0.71 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1TDP1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101146532-B | Pharmaceutical compounds | ASTEX THERAPEUTICS LTD | 2012-05-09 | — | — | CN | disclosed |