Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22310233 | 0.84 | SLC6A4 (0.53) | SMN1; SMN2HTTGAAKDM4ESTAT3 | |
| SCHEMBL28180305 | 0.84 | SLC6A3 (0.51) | SMN1; SMN2HTTKDM4ESTAT3HIF1A | |
| SCHEMBL28048741 | 0.83 | ALDH1A1 (0.54) | SMN1; SMN2HTTGAAALDH1A1HSD17B10 | |
| SCHEMBL9586577 | 0.83 | KDM4E (0.51) | SMN1; SMN2GAAKDM4EALDH1A1HPGD | |
| SCHEMBL948199 | 0.82 | KDM4E (0.50) | SMN1; SMN2HTTERCC1FEN1ERCC4 | |
| SCHEMBL28191526 | 0.82 | MAPT (0.56) | SMN1; SMN2ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL27849366 | 0.82 | NR4A2 (0.42) | SMN1; SMN2HTTKDM4EALDH1A1HPGD | |
| SCHEMBL3652340 | 0.80 | PTPN1 (0.42) | SMN1; SMN2LMNA | |
| SCHEMBL15051421 | 0.80 | GAA (0.49) | SMN1; SMN2HTTGAAKDM4ESTAT3 | |
| SCHEMBL954343 | 0.79 | BCAT2 (0.47) | SMN1; SMN2KDM4EALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116554103-A | Phenylpyrazoles and application thereof | 浙江大学 | 2023-08-08 | — | — | CN | disclosed |
| CN-114761000-A | Substituted 1, 6-naphthyridine inhibitors of CDK5 | 金翅雀生物公司 | 2022-07-15 | — | — | CN | disclosed |
| EP-3885346-A1 | AMINOPYRIMIDINE COMPOUND USED FOR INHIBITING ACTIVITY OF PROTEIN KINASE | Shenzhen TargetRx, Inc. (CN) | 2021-09-29 | — | — | EP | disclosed |
| WO-2020125391-A1 | AMINOPYRIMIDINE COMPOUND USED FOR INHIBITING ACTIVITY OF PROTEIN KINASE | 深圳市塔吉瑞生物医药有限公司 | 2020-06-25 | — | — | WO | disclosed |
| EP-2451450-B1 | Inhibitors of proline racemase enzymes for the treatment of Trypanosoma spp infections | PASTEUR INSTITUT (FR) | 2014-07-02 | — | — | EP | disclosed |
| EP-2451450-A1 | NEW INHIBITORS OF PROLINE RACEMASE ENZYMES | Institut Pasteur (FR) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011004323-A1 | NEW INHIBITORS OF PROLINE RACEMASE ENZYMES | INSTITUT PASTEUR (FR) | 2011-01-13 | — | — | WO | disclosed |
| EP-2272510-A1 | Inhibitors of the proline racemase of trypanosoma cruzi | Institut Pasteur (FR) | 2011-01-12 | — | — | EP | disclosed |