Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1959118 | 0.89 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL27850269 | 0.82 | KMT2A (0.48) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL27831709 | 0.75 | CYP2C9 (0.45) | ALDH1A1LMNAMAPTKMT2ACYP2C9 | |
| SCHEMBL1959654 | 0.74 | BCL2 (0.53) | — | |
| SCHEMBL27831767 | 0.74 | KMT2A (0.47) | ALDH1A1MAPTKMT2ACYP2C9CYP2C19 | |
| SCHEMBL27850282 | 0.74 | KMT2A (0.55) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL1958252 | 0.72 | BCL2 (0.44) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| Bromobenzene SCHEMBL28102861 | 0.72 | KMT2A (0.48) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL15897488 | 0.69 | SLC6A3 (0.60) | ALDH1A1LMNAMAPTKMT2ATSHR | |
| SCHEMBL26681715 | 0.69 | TSHR (0.55) | ALDH1A1LMNAMAPTMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102307872-B | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE 公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-102307872-A | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBOTT LAB | 2012-01-04 | — | — | CN | disclosed |