Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29082679 | 0.86 | NPC1 (0.50) | MAPTKMT2ANPC1MEN1USP2 | |
| SCHEMBL27868449 | 0.85 | ALDH1A1 (0.53) | MAPTKMT2ANPC1MEN1POLB | |
| SCHEMBL28826451 | 0.82 | SUCNR1 (0.47) | MAPTNPC1USP2POLBRAB9A | |
| SCHEMBL29082692 | 0.82 | NOTUM (0.46) | MAPTNPC1USP2POLBL3MBTL1 | |
| SCHEMBL27851505 | 0.80 | MAPT (0.45) | MAPTKMT2ANPC1MEN1USP2 | |
| SCHEMBL29082344 | 0.80 | POLB (0.46) | MAPTKMT2ANPC1ALOX12POLB | |
| SCHEMBL28923205 | 0.78 | NOTUM (0.56) | MAPTKMT2ANPC1ALOX12MEN1 | |
| SCHEMBL27921878 | 0.77 | PTGS2 (0.48) | KMT2ANPC1POLBHTTPTGS2 | |
| SCHEMBL2640766 | 0.73 | ALDH1A1 (0.70) | MAPTKMT2ANPC1ALOX12MEN1 | |
| SCHEMBL3823171 | 0.72 | NOTUM (0.68) | MAPTKMT2ANPC1ALOX12MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103209979-B | therapeutic agent 976 | ASTRAZENECA AB (SE) | 2016-02-10 | — | — | CN | disclosed |
| CN-103936751-A | Compound, preparation method and application thereof, and pharmaceutical composition having the same | ASTRAZENECA AB | 2014-07-23 | — | — | CN | disclosed |
| CN-102459279-B | Therapeutic agents 713 | ASTRAZENECA AB | 2014-06-25 | — | — | CN | disclosed |
| CN-102459279-A | Therapeutic agents 713 | ASTRAZENECA AB | 2012-05-16 | — | — | CN | disclosed |