Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29082679 | 0.85 | NPC1 (0.50) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL27851482 | 0.85 | MAPT (0.48) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 | |
| SCHEMBL27921878 | 0.85 | PTGS2 (0.48) | ALDH1A1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL28826451 | 0.82 | SUCNR1 (0.47) | ALDH1A1NOTUMRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL27851505 | 0.80 | MAPT (0.45) | LMNARAB9ASMN1; SMN2NPC1TSHR | |
| SCHEMBL28264126 | 0.79 | RAB9A (0.47) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29082692 | 0.76 | NOTUM (0.46) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 | |
| SCHEMBL13731090 | 0.74 | RAB9A (0.71) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 | |
| SCHEMBL21303556 | 0.74 | MAPT (0.66) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 | |
| SCHEMBL29291257 | 0.74 | ALDH1A1 (0.62) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103209979-B | therapeutic agent 976 | ASTRAZENECA AB (SE) | 2016-02-10 | — | — | CN | disclosed |
| CN-103936751-A | Compound, preparation method and application thereof, and pharmaceutical composition having the same | ASTRAZENECA AB | 2014-07-23 | — | — | CN | disclosed |
| CN-102459279-B | Therapeutic agents 713 | ASTRAZENECA AB | 2014-06-25 | — | — | CN | disclosed |
| CN-103209979-A | Therapeutic agent 976 | ASTRAZENECA AB | 2013-07-17 | — | — | CN | disclosed |
| CN-102459279-A | Therapeutic agents 713 | ASTRAZENECA AB | 2012-05-16 | — | — | CN | disclosed |