Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | ADK | P55263 | 2/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391944 | 0.74 | CA1 (0.47) | CA12CA1CA2CA9ADK | |
| SCHEMBL18967243 | 0.74 | ADK (0.39) | SRCCA12CA1CA2CA9 | |
| SCHEMBL19264154 | 0.73 | SRC (0.67) | SRCADKPDE11ALMNAHTT | |
| SCHEMBL868823 | 0.73 | ADK (0.49) | SRCCA12CA1CA2CA9 | |
| SCHEMBL24072610 | 0.72 | SRC (0.50) | SRCCA12CA1CA2CA9 | |
| SCHEMBL30372966 | 0.71 | ADK (0.38) | SRCCA12CA1CA2CA9 | |
| SCHEMBL21638052 | 0.71 | PI4KA (0.55) | SRCALDH1A1EGFRPTGS1PTGS2 | |
| SCHEMBL2732311 | 0.71 | PIP4K2A (0.41) | LMNAHTTMAPTALDH1A1 | |
| SCHEMBL30975023 | 0.70 | CA12 (0.53) | SRCCA12CA1CA2CA9 | |
| SCHEMBL17043110 | 0.69 | GAA (0.43) | SRCADKLMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010066629-A2 | NOVEL AZAINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010066629-A2 | NOVEL AZAINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-17 | — | — | WO | disclosed |
| US-20100144758-A1 | AZAINDOLE P2X3 AND P2X2/3 MODULATORS | DILLON MICHAEL PATRICK | 2010-06-10 | — | — | US | disclosed |
| US-20100144758-A1 | AZAINDOLE P2X3 AND P2X2/3 MODULATORS | DILLON MICHAEL PATRICK | 2010-06-10 | — | — | US | disclosed |
| US-20100144758-A1 | AZAINDOLE P2X3 AND P2X2/3 MODULATORS | DILLON MICHAEL PATRICK | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144758-A1 | AZAINDOLE P2X3 AND P2X2/3 MODULATORS | P2RX3, P2RX2, P2RX7 | SRC 2083/4885CA12 4144/4885CA1 3566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.