Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27854331 | 0.80 | FAAH (0.51) | FAAHCNR1CNR2MRGPRX1RIPK1 | |
| SCHEMBL9731442 | 0.79 | HCRTR1 (0.54) | ALDH1A1KMT2AMEN1LMNARAB9A | |
| SCHEMBL933677 | 0.79 | ALDH1A1 (0.57) | FAAHCNR1CNR2MRGPRX1RIPK1 | |
| SCHEMBL4000543 | 0.77 | ALDH1A1 (0.53) | FAAHCNR1CNR2MRGPRX1PARP15 | |
| SCHEMBL27983423 | 0.77 | FAAH (0.52) | FAAHCNR1CNR2MRGPRX1RIPK1 | |
| SCHEMBL11290605 | 0.77 | LMNA (0.49) | CNR1CNR2ALDH1A1KMT2AMEN1 | |
| SCHEMBL12379231 | 0.77 | SGMS2 (0.55) | ALDH1A1KMT2AMEN1SGMS2NPC1 | |
| SCHEMBL9731702 | 0.75 | LIG1 (0.58) | ALDH1A1KMT2AMEN1NPC1LMNA | |
| SCHEMBL12419023 | 0.75 | LMNA (0.55) | FAAHCNR1CNR2ALDH1A1KMT2A | |
| SCHEMBL6996948 | 0.73 | CTSD (0.50) | ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422846-B1 | Aroyl-ureas | WYETH JOHN & BROTHER LTD (GB) | 1994-02-16 | — | — | EP | claimed |
| EP-0422846-A2 | Aroyl-ureas | JOHN WYETH & BROTHER LIMITED (GB) | 1991-04-17 | — | — | EP | claimed |
| JP-3133986-A | — | — | None | — | — | JP | disclosed |
| EP-0422846-B1 | Aroyl-ureas | WYETH JOHN & BROTHER LTD (GB) | 1994-02-16 | — | — | EP | disclosed |
| US-5106843-A | Treatment of migraine, emesis, anxiety, gastrointestinal disorders, psychological disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0323077-B1 | HETEROCYCLIC COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 1991-09-11 | — | — | EP | disclosed |
| JP-H03133986-A | AROYL-LUREAS | JOHN WYETH & BROS LTD | 1991-06-07 | — | — | JP | disclosed |
| EP-0422846-A2 | Aroyl-ureas | JOHN WYETH & BROTHER LIMITED (GB) | 1991-04-17 | — | — | EP | disclosed |
| US-4983600-A | Antiemetics, antianxiety agents, gastrointestinal disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1991-01-08 | — | — | US | disclosed |
| EP-0323077-A1 | Heterocyclic compounds | JOHN WYETH & BROTHER LIMITED (GB) | 1989-07-05 | — | — | EP | disclosed |