Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.39 |
| ▸ | KIF5B | P33176 | 7/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | BLK | P51451 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 7/20 | 0.35 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1933318 | 0.84 | RET (0.52) | RETKIF5BKDRKCNH2CCDC6 | |
| SCHEMBL27880616 | 0.79 | ADK (0.47) | RETKIF5BKDRKCNH2CCDC6 | |
| SCHEMBL23892218 | 0.77 | PRMT5 (0.47) | PRMT5WDR77SLC22A12NNMTPIP4K2A | |
| SCHEMBL1442008 | 0.77 | UBA6 (0.35) | RETKIF5BKDRPRMT5WDR77 | |
| SCHEMBL27864278 | 0.74 | NNMT (0.33) | RETKIF5BKDRPRMT5WDR77 | |
| SCHEMBL16769947 | 0.74 | PRMT5 (0.44) | PRMT5WDR77SLC22A12ABL1NNMT | |
| SCHEMBL1795549 | 0.73 | PRMT5 (0.45) | PRMT5WDR77NNMT | |
| SCHEMBL514777 | 0.72 | GPR119 (0.43) | KCNH2ACACBPIP4K2A | |
| SCHEMBL21130182 | 0.71 | PIP4K2A (0.40) | PRMT5WDR77SLC22A12ACACBNNMT | |
| SCHEMBL16967987 | 0.71 | PIP4K2A (0.49) | PRMT5WDR77SLC22A12SRCACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102712648-A | Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls | NOVARTIS AG | 2012-10-03 | — | — | CN | disclosed |
| CN-102596963-A | Ether derivatives of bicyclic heteroaryls | NOVARTIS AG | 2012-07-18 | — | — | CN | disclosed |