Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2428977 | 0.87 | PTGDR2 (0.35) | LMNAPTGDR2KDM4CHTTKDM4E | |
| SCHEMBL3083354 | 0.82 | LMNA (0.47) | LMNAALOX5BACE1ELANEHTT | |
| SCHEMBL27865242 | 0.78 | ALOX5 (0.36) | LMNADRD2DRD1ALOX5BACE1 | |
| SCHEMBL3672142 | 0.77 | KDM4E (0.44) | LMNAALOX5BACE1ELANEHTT | |
| SCHEMBL27865228 | 0.74 | LMNA (0.40) | LMNAALOX5BACE1ELANEHTT | |
| SCHEMBL27671451 | 0.74 | LMNA (0.40) | LMNAALOX5BACE1ELANEHTT | |
| SCHEMBL1224619 | 0.71 | ACVRL1 (0.33) | LMNAPTGDR2KDM4CKDM4ETP53 | |
| SCHEMBL509185 | 0.71 | PTGDR2 (0.39) | PTGDR2KDM4CKDM4EGAAMAPT | |
| SCHEMBL27848174 | 0.71 | LMNA (0.37) | LMNAALOX5BACE1ELANEHTT | |
| SCHEMBL2428979 | 0.71 | KDM4E (0.38) | LMNAPTGDR2KDM4CKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102421759-A | Pyridazinone compounds and use thereof | SUMITOMO CHEMICAL CO | 2012-04-18 | — | — | CN | disclosed |