Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4131617 | 1.00 | CLK1 (0.54) | CLK1PDPK1DYRK1ACASP3SENP8 | |
| SCHEMBL10114641 | 0.85 | CYP1A2 (0.56) | CLK1DYRK1ACASP3SENP8SENP7 | |
| SCHEMBL13204244 | 0.85 | CYP1A2 (0.56) | CLK1DYRK1ACASP3SENP8SENP7 | |
| SCHEMBL13985632 | 0.83 | PDPK1 (0.45) | CLK1PDPK1DYRK1ACASP3SENP8 | |
| SCHEMBL14424167 | 0.78 | TP53 (0.60) | NPC1RAB9AKMT2ASMN1; SMN2LMNA | |
| SCHEMBL10114501 | 0.78 | TP53 (0.60) | NPC1RAB9AKMT2ASMN1; SMN2LMNA | |
| SCHEMBL10113384 | 0.78 | CSNK2A2 (0.54) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13203876 | 0.78 | CSNK2A2 (0.54) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12864673 | 0.77 | NPY5R (0.58) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL10113061 | 0.77 | NPY5R (0.58) | MEN1KMT2ASMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133513-B2 | Solid preparation having improved solubility | SHIONOGI & CO., LTD. (JP) | 2012-03-13 | — | — | US | disclosed |
| US-20110060145-A1 | PROCESS FOR PRODUCTION OF COMPOUND HAVING ANTAGONISTIC ACTIVITY ON NPYY5 RECEPTOR, AND USEFUL CRYSTAL | SHIONOGI & CO., LTD. (JP) | 2011-03-10 | — | — | US | disclosed |
| US-7795471-B2 | Process for trans-4-amino-1-cyclohexanecarboxylic acid derivatives | SHIONOGI & CO., LTD. (JP) | 2010-09-14 | — | — | US | disclosed |
| US-7795471-B2 | Process for trans-4-amino-1-cyclohexanecarboxylic acid derivatives | SHIONOGI & CO., LTD. (JP) | 2010-09-14 | — | — | US | disclosed |
| US-20090221817-A1 | Triethylamine was added dropwise to a solution of 2-methylpropane-2-sulfinyl chloride and methyl trans-4-amino-1-cyclohexane carboxylate p-toluenesulfonate in tetrahydrofuran solvent to obtain Methyl trans-4-(2-methylpropane-2-sulfonylamino)cyclohexanecarboxylate; hydrolysis; oxidation; intermediates | SHIONOGI & CO., LTD. (JP) | 2009-09-03 | — | — | US | disclosed |
| US-20090221817-A1 | Triethylamine was added dropwise to a solution of 2-methylpropane-2-sulfinyl chloride and methyl trans-4-amino-1-cyclohexane carboxylate p-toluenesulfonate in tetrahydrofuran solvent to obtain Methyl trans-4-(2-methylpropane-2-sulfonylamino)cyclohexanecarboxylate; hydrolysis; oxidation; intermediates | SHIONOGI & CO., LTD. (JP) | 2009-09-03 | — | — | US | disclosed |
| US-7547800-B2 | Process for trans-4-amino-1-cyclohexanecarboxylic acid derivatives | SHIONOGI & CO., LTD. (JP) | 2009-06-16 | — | — | US | disclosed |
| US-7547800-B2 | Process for trans-4-amino-1-cyclohexanecarboxylic acid derivatives | SHIONOGI & CO., LTD. (JP) | 2009-06-16 | — | — | US | disclosed |
| US-20090105312-A1 | SOLID PREPARATION HAVING IMPROVED SOLUBILITY | SHIONOGI & CO., LTD. (JP) | 2009-04-23 | — | — | US | disclosed |
| US-20090043094-A1 | PROCESS FOR TRANS-4-AMINO-1-CYCLOHEXANECARBOXYLIC ACID DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2009-02-12 | — | — | US | disclosed |
| US-20090043094-A1 | PROCESS FOR TRANS-4-AMINO-1-CYCLOHEXANECARBOXYLIC ACID DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2009-02-12 | — | — | US | disclosed |
| US-7459580-B2 | Process for trans-4-amino-1-cyclohexanecarboxilic acid derivatives | SHIONOGI & CO., LTD. (JP) | 2008-12-02 | — | — | US | disclosed |
| US-20080039662-A1 | PROCESS FOR TRANS-4-AMINO-1-CYCLOHEXANECARBOXILIC ACID DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2008-02-14 | — | — | US | disclosed |
| US-7314950-B2 | Process for producing trans-4-amino-1-cyclohexanecarboxilic acid derivative | SHIONOGI & CO., LTD. (JP) | 2008-01-01 | — | — | US | disclosed |
| US-7314950-B2 | Process for producing trans-4-amino-1-cyclohexanecarboxilic acid derivative | SHIONOGI & CO., LTD. (JP) | 2008-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090043094-A1 | PROCESS FOR TRANS-4-AMINO-1-CYCLOHEXANECARBOXYLIC ACID DERIVATIVES | ACMSD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, AADAT | CLK1 2500/4885PDPK1 2489/4885DYRK1A 2674/4885 |
| US-20080039662-A1 | PROCESS FOR TRANS-4-AMINO-1-CYCLOHEXANECARBOXILIC ACID DERIVATIVES | AADAT, ACMSD, AAAS | CLK1 3025/4885PDPK1 2980/4885DYRK1A 3463/4885 |
| US-20110060145-A1 | PROCESS FOR PRODUCTION OF COMPOUND HAVING ANTAGONISTIC ACTIVITY ON NPYY5 RECEPTOR, AND USEFUL CRYSTAL | NPY5R, NPY1R, NPY2R | CLK1 1587/4885PDPK1 2352/4885DYRK1A 324/4885 |
| US-20090221817-A1 | Triethylamine was added dropwise to a solution of 2-methylpropane-2-sulfinyl chloride and methyl trans-4-amino-1-cyclohexane carboxylate p-toluenesulfonate in tetrahydrofuran solvent to obtain Methyl trans-4-(2-methylpropane-2-sulfonylamino)cyclohexanecarboxylate; hydrolysis; oxidation; intermediates | TST, ACMSD, PNMT | CLK1 3124/4885PDPK1 3532/4885DYRK1A 1327/4885 |
| US-20090105312-A1 | SOLID PREPARATION HAVING IMPROVED SOLUBILITY | NUDT1, PDE7A, SLC7A1 | CLK1 3844/4885PDPK1 4172/4885DYRK1A 2053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.