Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB11 | A5LHX3 | 7/20 | 0.41 |
| ▸ | PSMA7 | O14818 | 7/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 7/20 | 0.41 |
| ▸ | PSMA1 | P25786 | 7/20 | 0.41 |
| ▸ | PSMA2 | P25787 | 7/20 | 0.41 |
| ▸ | PSMA3 | P25788 | 7/20 | 0.41 |
| ▸ | PSMA4 | P25789 | 7/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 7/20 | 0.41 |
| ▸ | PSMB9 | P28065 | 7/20 | 0.41 |
| ▸ | PSMA5 | P28066 | 7/20 | 0.41 |
| ▸ | PSMB4 | P28070 | 7/20 | 0.41 |
| ▸ | PSMB6 | P28072 | 7/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 7/20 | 0.41 |
| ▸ | PSMB10 | P40306 | 7/20 | 0.41 |
| ▸ | PSMB3 | P49720 | 7/20 | 0.41 |
| ▸ | PSMB2 | P49721 | 7/20 | 0.41 |
| ▸ | PSMA6 | P60900 | 7/20 | 0.41 |
| ▸ | PSMA8 | Q8TAA3 | 7/20 | 0.41 |
| ▸ | PSMB7 | Q99436 | 7/20 | 0.41 |
| ▸ | LONP1 | P36776 | 8/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28766234 | 1.00 | PSMB11 (0.41) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL28602834 | 0.90 | SLC7A5 (0.38) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL28611443 | 0.88 | POLB (0.43) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL28614526 | 0.86 | RAB9A (0.46) | ALDH1A1POLB | |
| SCHEMBL28766231 | 0.84 | POLB (0.40) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL523434 | 0.79 | PSMB5 (0.41) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL7423057 | 0.76 | CYP1A2 (0.47) | ALDH1A1CYP1A2 | |
| SCHEMBL7423062 | 0.76 | CYP1A2 (0.47) | ALDH1A1CYP1A2 | |
| SCHEMBL28613880 | 0.75 | POLB (0.41) | ALDH1A1POLBLMNACYP1A2CYP2C9 | |
| SCHEMBL27883394 | 0.70 | TSHR (0.40) | ALDH1A1POLBLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102659919-B | A kind of synthetic method of Velcade | HEFEI UNIVERSITY OF TECHNOLOGY (CN) | 2016-03-30 | — | — | CN | claimed |
| CN-102659919-A | Synthetic method of bortezomib | UNIV HEFEI TECHNOLOGY | 2012-09-12 | — | — | CN | claimed |
| CN-106008665-B | Compound with tumor proliferation inhibition function and preparation method and application thereof | 北京大学 | 2021-03-16 | — | — | CN | disclosed |
| CN-110372613-A | A kind of 2,3,6- tri- replaces the high efficiency preparation method of pyrazine nitrogen oxygen class compound | 江南大学 | 2019-10-25 | — | — | CN | disclosed |
| CN-102659919-B | A kind of synthetic method of Velcade | HEFEI UNIVERSITY OF TECHNOLOGY (CN) | 2016-03-30 | — | — | CN | disclosed |
| CN-102659919-B | A kind of synthetic method of Velcade | HEFEI UNIVERSITY OF TECHNOLOGY (CN) | 2016-03-30 | — | — | CN | disclosed |
| CN-102659919-A | Synthetic method of bortezomib | UNIV HEFEI TECHNOLOGY | 2012-09-12 | — | — | CN | disclosed |
| CN-102659919-A | Synthetic method of bortezomib | UNIV HEFEI TECHNOLOGY | 2012-09-12 | — | — | CN | disclosed |