Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28038078 | 0.87 | HTT (0.97) | HTTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27876284 | 0.84 | ALDH1A1 (1.00) | HTTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27656401 | 0.80 | KMT2A (0.55) | HTTALDH1A1RAB9ANPC1MEN1 | |
| SCHEMBL27859664 | 0.79 | HTT (0.71) | HTTALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL24177790 | 0.78 | ALDH1A1 (0.60) | HTTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL19442008 | 0.78 | RAB9A (0.60) | ALDH1A1RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL11980704 | 0.77 | RAB9A (0.64) | ALDH1A1RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL27859665 | 0.76 | GAA (0.57) | HTTALDH1A1RAB9ANPC1KDM4E | |
| SCHEMBL9792219 | 0.76 | ALDH1A1 (0.88) | HTTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL31757952 | 0.74 | KMT2A (0.66) | HTTALDH1A1NPC1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482249-B | TOFA analogs for treating skin disorders or conditions | 德米拉(加拿大)公司 | 2016-06-08 | — | — | CN | claimed |
| CN-105017187-A | TOFA analogs useful in treating dermatological disorders or conditions | VALOCOR THERAPEUTICS INC | 2015-11-04 | — | — | CN | claimed |
| CN-102482249-A | TOFA analogs for treating skin disorders or conditions | VALOCOR THERAPEUTICS INC | 2012-05-30 | — | — | CN | claimed |
| CN-105017187-B | TOFA analogs for treating skin disorder or morbid state | 德米拉(加拿大)公司 | 2017-10-24 | — | — | CN | disclosed |
| CN-102482249-B | TOFA analogs for treating skin disorders or conditions | 德米拉(加拿大)公司 | 2016-06-08 | — | — | CN | disclosed |
| CN-105017187-A | TOFA analogs useful in treating dermatological disorders or conditions | VALOCOR THERAPEUTICS INC | 2015-11-04 | — | — | CN | disclosed |
| CN-102482249-A | TOFA analogs for treating skin disorders or conditions | VALOCOR THERAPEUTICS INC | 2012-05-30 | — | — | CN | disclosed |