Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11985078 | 0.87 | HTT (0.60) | RAB9ANPC1L3MBTL1SMN1; SMN2 | |
| SCHEMBL11980704 | 0.85 | RAB9A (0.64) | RAB9ANPC1POLBL3MBTL1FKBP1A | |
| SCHEMBL19442006 | 0.83 | ALDH1A1 (0.69) | RAB9ANPC1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL15268192 | 0.80 | CASP6 (0.46) | RAB9APOLBKDM4EMEN1KMT2A | |
| SCHEMBL19442012 | 0.79 | KDM4E (0.50) | RAB9APOLBSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL11985172 | 0.78 | POLB (0.61) | RAB9ANPC1POLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL19442051 | 0.78 | ATM (0.63) | L3MBTL1SMN1; SMN2KDM4EKMT2AALDH1A1 | |
| SCHEMBL27876376 | 0.78 | HTT (0.80) | RAB9ANPC1POLBSMN1; SMN2KDM4E | |
| SCHEMBL992135 | 0.76 | POLB (0.61) | RAB9ANPC1POLBL3MBTL1FKBP1A | |
| SCHEMBL18609175 | 0.73 | RAB9A (1.00) | RAB9ANPC1POLBFKBP1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782382-B2 | TOFA analogs useful in treating dermatological disorders or conditions | DERMIRA (CANADA), INC. (US) | 2017-10-10 | — | — | US | disclosed |