Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111247 | 0.98 | PRKCZ (0.46) | PRKCZADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL29375416 | 0.98 | PRKCZ (0.46) | PRKCZADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL27680594 | 0.88 | PRKCZ (0.40) | PRKCZADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL9871846 | 0.80 | CYP3A4 (0.46) | PRKCZADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL4068814 | 0.78 | HASPIN (0.39) | PRKCZADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL12441263 | 0.74 | IMPDH2 (0.48) | ADRA2AADRA2BADRA2CADRA1AKDM4E | |
| SCHEMBL20873066 | 0.73 | PRKCZ (0.64) | PRKCZADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL19656321 | 0.73 | IMPDH2 (0.47) | PRKCZADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL29862478 | 0.73 | IMPDH2 (0.47) | PRKCZADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL6993140 | 0.72 | CYP11B1 (0.44) | PRKCZKDM4ECYP11B2CYP11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103002900-A | Transcription factor decoys | PROCARTA BIOSYSTEMS LTD | 2013-03-27 | — | — | CN | disclosed |
| CN-102791295-A | Nucleic acid complexes | PROCARTA BIOSYSTEMS LTD | 2012-11-21 | — | — | CN | disclosed |