Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CLK3 | P49761 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27567921 | 0.86 | NPC1 (0.47) | CYP11B1CYP11B2DYRK1ACYP19A1CYP17A1 | |
| SCHEMBL17691561 | 0.79 | CYP11B1 (0.47) | CYP11B1CYP11B2DYRK3CLK1CLK2 | |
| SCHEMBL20033090 | 0.76 | HSD17B1 (0.49) | GRIN2DGRIN2AGRIN2BGRIN2CESR1 | |
| SCHEMBL30099343 | 0.75 | NOS1 (0.39) | CYP11B1CYP11B2CDK5DYRK1ACLK4 | |
| SCHEMBL5497704 | 0.75 | NOS1 (0.39) | CYP11B1CYP11B2CDK5DYRK1ACLK4 | |
| SCHEMBL29375416 | 0.74 | PRKCZ (0.46) | CYP11B1CYP11B2CYP17A1ALDH1A1MAPK1 | |
| SCHEMBL111247 | 0.74 | PRKCZ (0.46) | CYP11B1CYP11B2CYP17A1ALDH1A1MAPK1 | |
| Iodide SCHEMBL27879062 | 0.72 | PRKCZ (0.44) | CYP11B1CYP11B2CYP17A1ALDH1A1MAPK1 | |
| SCHEMBL20975068 | 0.72 | CYP11B2 (0.37) | CYP11B1CYP11B2CLK1CLK2DYRK1A | |
| SCHEMBL29709757 | 0.72 | NOS1 (0.37) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6248738-B1 | ANTIULCER AGENTS, ANGIOGENESIS INHIBITORS, ANTIMETASTASIS AGENTS, ANTITUMOR AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |
| EP-1023268-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | Pfizer Limited (GB) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020608-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |