Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31657726 | 0.91 | CHRNA7 (0.41) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL2791842 | 0.89 | CHRNA7 (0.41) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL18256178 | 0.88 | PSMD14 (0.44) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL1629035 | 0.87 | CHRNA7 (0.42) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL25369277 | 0.86 | PSMD14 (0.46) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL28644851 | 0.86 | PSMD14 (0.46) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL18256109 | 0.86 | PSMD14 (0.41) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL419353 | 0.85 | CHRNA7 (0.50) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL475755 | 0.84 | PSMD14 (0.46) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL26460127 | 0.83 | PSMD14 (0.43) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12516143-B2 | Polystyrene-based polyampholyte having upper critical solution temperature, and application for same | TOSOH FINECHEM CORPORATION (JP) | 2026-01-06 | — | — | US | disclosed |
| CN-113597439-B | Amphoteric polyelectrolytes of novel polystyrene substrates with highest critical co-solvent temperature and use thereof | 东曹精细化工株式会社 | 2024-08-02 | — | — | CN | disclosed |
| US-20220073661-A1 | NOVEL POLYSTYRENE-BASED POLYAMPHOLYTE HAVING UPPER CRITICAL SOLUTION TEMPERATURE, AND APPLICATION FOR SAME | TOSOH FINECHEM CORPORATION (JP) | 2022-03-10 | — | — | US | disclosed |
| CN-113597439-A | Novel polystyrene-based amphoteric polyelectrolytes having a maximum critical eutectic temperature and uses thereof | 东曹精细化工株式会社 | 2021-11-02 | — | — | CN | disclosed |
| WO-2020188839-A1 | NOVEL POLYSTYRENE-BASED POLYAMPHOLYTE HAVING UPPER CRITICAL SOLUTION TEMPERATURE, AND APPLICATION FOR SAME | 東ソー・ファインケム株式会社 | 2020-09-24 | — | — | WO | disclosed |
| US-20130228520-A1 | POLYMER COATINGS THAT RESIST ADSORPTION OF PROTEINS | GIN DOUGLAS L (US) | 2013-09-05 | — | — | US | disclosed |
| US-20100096327-A1 | POLYMER COATINGS THAT RESIST ADSORPTION OF PROTEINS | NAVY, SECRETARY OF THE UNITED STATES OF AMERICA | 2010-04-22 | — | — | US | disclosed |