Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 4/20 | 0.42 |
| ▸ | GABRD | O14764 | 4/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.42 |
| ▸ | GABRE | P78334 | 4/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27703245 | 0.81 | LMNA (0.38) | LMNAACHEALOX5KDM4EHTT | |
| SCHEMBL27570781 | 0.81 | LMNA (0.41) | LMNAACHEALOX5KDM4EHTT | |
| SCHEMBL27789443 | 0.80 | GABRP (0.37) | NOS3NOS1NOS2GABRPGABRD | |
| SCHEMBL2829068 | 0.74 | GABRP (0.50) | NOS3NOS1NOS2GABRPGABRD | |
| SCHEMBL15544743 | 0.74 | NOS2 (0.54) | NOS3NOS1NOS2GABRPGABRD | |
| SCHEMBL16834762 | 0.74 | LMNA (0.39) | LMNAACHEALOX5KDM4ETP53 | |
| SCHEMBL15544912 | 0.74 | KDM4E (0.42) | LMNAKDM4ETSHRALDH1A1HPGD | |
| SCHEMBL27850349 | 0.70 | GRM5 (0.40) | NOS3NOS2LMNAALOX5KDM4E | |
| SCHEMBL27878809 | 0.70 | ALOX5 (0.35) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28783444 | 0.69 | ALOX5 (0.36) | LMNAALOX5KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102762561-A | Gamma secretase modulaters | HOFFMANN LA ROCHE | 2012-10-31 | — | — | CN | disclosed |