Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 3/20 | 0.38 |
| ▸ | BTK | Q06187 | 4/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901095 | 0.86 | HPGDS (0.46) | PROKR1KDM4E | |
| SCHEMBL2789127 | 0.81 | PROKR1 (0.60) | PROKR1KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL23704300 | 0.70 | PROKR1 (0.45) | PROKR1SMN1; SMN2PDE2ARAB9AKMT2A | |
| SCHEMBL26837306 | 0.70 | MAPK10 (0.36) | KDM4EKMT2A | |
| SCHEMBL2789761 | 0.69 | PROKR1 (0.43) | PROKR1NPSR1BTKKMT2A | |
| SCHEMBL7893351 | 0.67 | PROKR1 (0.55) | PROKR1 | |
| SCHEMBL4090402 | 0.67 | MCL1 (0.62) | GAAKDM4EALDH1A1TSHRHTT | |
| SCHEMBL4754555 | 0.67 | PROKR1 (0.48) | PROKR1PDE2A | |
| SCHEMBL3312540 | 0.66 | ALDH1A1 (0.62) | PROKR1ALDH1A1LMNATP53TSHR | |
| SCHEMBL2791157 | 0.65 | TRPV3 (0.43) | ALDH1A1BTKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |