Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7892876 | 0.88 | STS (0.46) | HPGDSJAK2JAK1USP30KDM1A | |
| SCHEMBL2792693 | 0.87 | GPR119 (0.46) | HPGDSJAK2JAK1BRD3TRPV3 | |
| SCHEMBL2791503 | 0.86 | PROKR1 (0.43) | PROKR1KDM4E | |
| SCHEMBL7893351 | 0.83 | PROKR1 (0.55) | HPGDSJAK2JAK1BRD3USP30 | |
| SCHEMBL7904115 | 0.80 | CCNK (0.47) | HPGDSJAK2JAK1BRD3TRPV3 | |
| SCHEMBL2791157 | 0.80 | TRPV3 (0.43) | HPGDSJAK2JAK1BRD3TRPV3 | |
| SCHEMBL7897983 | 0.75 | MAPKAPK2 (0.53) | BRD3PROKR1 | |
| SCHEMBL2789816 | 0.74 | HPGDS (0.48) | HPGDSJAK2JAK1BRD3USP30 | |
| SCHEMBL19405061 | 0.74 | GPR119 (0.52) | HPGDSTRPV3USP30GPR119KDM4E | |
| SCHEMBL23704259 | 0.73 | GPR119 (0.46) | HPGDSJAK2JAK1BRD3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |