Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 5/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | BCL2 | P10415 | 4/20 | 0.50 |
| ▸ | BECN1 | Q14457 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27936621 | 0.87 | TERT (0.66) | TERTCACNA1HRAF1BRAFMAPK8 | |
| SCHEMBL27936466 | 0.85 | CACNA1H (0.68) | TERTCACNA1H | |
| SCHEMBL27936508 | 0.79 | TERT (0.69) | TERTMEN1KMT2ANPSR1 | |
| SCHEMBL27936536 | 0.77 | MEN1 (0.49) | TERTPKMMEN1KMT2ACACNA1H | |
| SCHEMBL27918012 | 0.70 | MAOB (0.64) | MEN1KMT2ALMNANPSR1EGFR | |
| SCHEMBL3313107 | 0.67 | KMT2A (0.62) | MEN1KMT2ASMN1; SMN2EGFR | |
| SCHEMBL29808004 | 0.67 | BRAF (1.00) | TERTCACNA1HRAF1BRAFMAPK8 | |
| SCHEMBL10244111 | 0.67 | ALDH1A1 (0.47) | PKMLMNAHPGDSMN1; SMN2 | |
| SCHEMBL23269397 | 0.67 | BCL2 (1.00) | CACNA1HBCL2BECN1 | |
| SCHEMBL14541165 | 0.66 | CACNA1H (0.78) | PKMMEN1KMT2ACACNA1HBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103304546-A | Pyrazoline derivatives comprising 1,4-benzodioxan structure, and preparation method and application thereof | NANJING UNIVERSITY OF TECHNOLOGY | 2013-09-18 | — | — | CN | disclosed |