Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27923627 | 0.84 | KCNA3 (0.34) | KCNH2TAAR1 | |
| SCHEMBL27905695 | 0.84 | SLC6A2 (0.35) | LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27905680 | 0.84 | NPC1 (0.36) | MAPK1KCNH2 | |
| SCHEMBL27905687 | 0.81 | L3MBTL1 (0.41) | LMNAHTTDRD2KMT2AKDM4E | |
| SCHEMBL27923629 | 0.77 | CYP1A2 (0.35) | SMN1; SMN2DRD2KMT2AMEN1CYP2D6 | |
| SCHEMBL16539602 | 0.76 | LMNA (0.46) | LMNAMAPK1HTTSMN1; SMN2DRD2 | |
| SCHEMBL16539362 | 0.76 | WDR5 (0.47) | LMNAMAPK1HTTSMN1; SMN2DRD2 | |
| SCHEMBL27905697 | 0.74 | PPARD (0.39) | DRD2 | |
| SCHEMBL1532086 | 0.74 | CYP1A2 (0.43) | LMNAMAPK1HTTSMN1; SMN2DRD2 | |
| SCHEMBL27905683 | 0.73 | SLC6A2 (0.36) | LMNASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103097333-A | Spirocyclically substituted 1,3-propane dioxide derivatives, methods for the production thereof and use of the same as medicament | SANOFI SA | 2013-05-08 | — | — | CN | disclosed |