Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 4/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | BMP1 | P13497 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27931106 | 1.00 | APLNR (0.43) | APLNRAAK1DGAT1ACACBBMP1 | |
| SCHEMBL27796919 | 0.82 | APLNR (0.37) | APLNRAAK1MAPTKMT2A | |
| SCHEMBL28948407 | 0.79 | APLNR (0.46) | APLNRAAK1DGAT1ACACBFPR2 | |
| SCHEMBL25222547 | 0.78 | ALOX5 (0.43) | FPR2LMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL27828808 | 0.78 | ALOX5 (0.43) | FPR2LMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL25222546 | 0.78 | ALOX5 (0.43) | FPR2LMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL27913119 | 0.78 | APLNR (0.44) | APLNRAAK1DGAT1FPR2LMNA | |
| SCHEMBL27498670 | 0.76 | ALDH1A1 (0.37) | AAK1ALDH1A1L3MBTL1 | |
| SCHEMBL27776366 | 0.76 | HTT (0.40) | AAK1NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL27698022 | 0.76 | DGAT1 (0.44) | AAK1DGAT1BMP1FPR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103249727-B | Biaryl amide derivatives | 霍夫曼-拉罗奇有限公司 | 2016-08-10 | — | — | CN | disclosed |
| CN-103249727-A | New biaryl amide derivatives | HOFFMANN LA ROCHE | 2013-08-14 | — | — | CN | disclosed |