Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27943399 | 0.85 | CREBBP (0.38) | CNR2USP2HSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL27943380 | 0.81 | CNR2 (0.50) | CNR2ALDH1A1CYP1A2TSHRHPGD | |
| SCHEMBL27943408 | 0.81 | DRD2 (0.45) | ALDH1A1CYP1A2CYP2D6TSHRSMN1; SMN2 | |
| SCHEMBL27943391 | 0.78 | AR (0.39) | ALDH1A1SMN1; SMN2LRRK2 | |
| SCHEMBL27943552 | 0.72 | PKM (0.36) | CYP3A4CYP1A2TP53CYP2D6SMN1; SMN2 | |
| SCHEMBL2184950 | 0.70 | ADRB2 (0.35) | — | |
| SCHEMBL14060017 | 0.68 | ALDH1A1 (0.40) | CNR2MAOBALDH1A1MAPK1HPGD | |
| SCHEMBL27953743 | 0.67 | SLC6A4 (0.45) | CYP3A4CYP1A2TP53CYP2D6 | |
| SCHEMBL14060813 | 0.67 | MAP4K1 (0.43) | — | |
| SCHEMBL14060078 | 0.66 | MEN1 (0.43) | CNR2USP2HSD17B10ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | claimed |
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | disclosed |