Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27943380 | 0.74 | CNR2 (0.50) | KMT2ACYP1A2HTTGAARAB9A | |
| SCHEMBL27943408 | 0.74 | DRD2 (0.45) | HTR3EHTR3BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL27953743 | 0.73 | SLC6A4 (0.45) | ADRB1HTR3EHTR3BTP53CYP1A2 | |
| SCHEMBL10999344 | 0.73 | CYP2C9 (0.63) | PKMKMT2AADRB1HTR3EHTR3B | |
| SCHEMBL27943382 | 0.72 | CNR2 (0.39) | TP53CYP1A2CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL27943391 | 0.72 | AR (0.39) | GAASMN1; SMN2 | |
| SCHEMBL11519970 | 0.69 | ADRB1 (0.61) | KMT2AADRB1HTR3EHTR3BTP53 | |
| SCHEMBL27943399 | 0.68 | CREBBP (0.38) | KMT2ATP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12208591 | 0.68 | HTR3E (0.56) | PKMKMT2AADRB1HTR3EHTR3B | |
| SCHEMBL2481499 | 0.68 | RORC (0.39) | PKMADRB1HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | claimed |
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | disclosed |