Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27926206 | 0.85 | LMNA (0.38) | RAB9ALMNASMN1; SMN2HSD17B10MAPK10 | |
| Tert-Butyl Formate SCHEMBL27945215 | 0.77 | MAP2K4 (0.36) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Tert-Butyl Formate SCHEMBL27945219 | 0.69 | MAP2K4 (0.36) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL27811452 | 0.68 | MAP2K4 (0.52) | RAB9ALMNASMN1; SMN2HSD17B10MAPK10 | |
| SCHEMBL27926203 | 0.68 | KDM4E (0.49) | RAB9ALMNASMN1; SMN2HSD17B10MAPK10 | |
| SCHEMBL27305897 | 0.67 | ELANE (0.52) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL25097632 | 0.66 | NTRK1 (0.40) | NTRK1LRRK2MAP2K4 | |
| SCHEMBL28290004 | 0.66 | ENPP2 (0.49) | MAPTALDH1A1USP2NPSR1KDM4E | |
| SCHEMBL13811550 | 0.65 | MAOB (0.54) | RAB9ALMNASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL7257833 | 0.65 | LMNA (0.47) | RAB9ALMNASMN1; SMN2HSD17B10MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103429585-B | Indazolyl triazole derivatives as interleukin-1 receptor associated kinase inhibitors | MERCK SERONO SA | 2015-07-08 | — | — | CN | disclosed |
| CN-103429585-A | Indazolyl triazole derivatives as interleukin-1 receptor associated kinase inhibitors | MERCK SERONO SA | 2013-12-04 | — | — | CN | disclosed |