Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.45 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 6/20 | 0.36 |
| ▸ | HTR2C | P28335 | 6/20 | 0.36 |
| ▸ | HTR2B | P41595 | 5/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27943552 | 0.73 | PKM (0.36) | SLC6A4HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL3657785 | 0.73 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3MAPKAPK2HTR2A | |
| SCHEMBL19357378 | 0.72 | SLC6A4 (0.48) | SLC6A4SLC6A2SLC6A3WEE1HTR2A | |
| Hydrochloric Acid SCHEMBL2860102 | 0.72 | SLC6A4 (0.57) | SLC6A4SLC6A2SLC6A3MAPKAPK2HTR2A | |
| SCHEMBL12892216 | 0.69 | ADRB1 (0.57) | SLC6A4SLC6A2SLC6A3ADRB1 | |
| SCHEMBL27943408 | 0.69 | DRD2 (0.45) | HTR6HTR3EHTR3BCYP1A2CYP2D6 | |
| SCHEMBL27943380 | 0.69 | CNR2 (0.50) | CYP1A2HTT | |
| SCHEMBL1814949 | 0.68 | ADRB1 (0.56) | SLC6A4SLC6A2SLC6A3HTR2AHTR2C | |
| SCHEMBL26774776 | 0.68 | SLC6A2 (0.65) | SLC6A4SLC6A2SLC6A3WEE1MAPKAPK2 | |
| SCHEMBL4313256 | 0.68 | SLC6A2 (0.45) | SLC6A4SLC6A2SLC6A3WEE1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | claimed |
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | disclosed |