Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474571 | 0.76 | MEN1 (0.40) | MEN1KMT2AMDM2LMNAALDH1A1 | |
| SCHEMBL474406 | 0.75 | ALOX15 (0.43) | MEN1KMT2ALMNAALDH1A1TP53 | |
| SCHEMBL474525 | 0.68 | SMN1; SMN2 (0.52) | ALDH1A1HPGDPOLBPKM | |
| SCHEMBL480035 | 0.67 | ROCK2 (0.42) | MEN1KMT2AMDM2LMNA | |
| SCHEMBL474390 | 0.67 | ALDH1A1 (0.46) | MEN1KMT2ALMNAALDH1A1ALOX15 | |
| SCHEMBL480081 | 0.66 | ROCK2 (0.40) | MEN1KMT2AMDM2LMNA | |
| SCHEMBL27974415 | 0.66 | PTGS2 (0.45) | LMNA | |
| SCHEMBL473899 | 0.65 | RECQL (0.42) | KMT2AMDM2ALDH1A1TP53GAA | |
| SCHEMBL473938 | 0.65 | KMO (0.43) | ALDH1A1HPGDPOLB | |
| SCHEMBL28034745 | 0.61 | HTR2A (0.44) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102356068-B | 2,3-diaryl- or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds | HOFFMANN LA ROCHE | 2014-04-23 | — | — | CN | disclosed |