Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Acetamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CA5A | P35218 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetamide SCHEMBL5320059 | 0.96 | — | — | |
| Acetamide SCHEMBL28019241 | 0.96 | BLM (0.61) | BLMLMNAPMP22ALOX15CRBN | |
| Acetone SCHEMBL29086949 | 0.85 | LMNA (0.50) | BLMLMNAPMP22ALOX15CA2 | |
| Urea SCHEMBL28006959 | 0.85 | LMNA (0.50) | BLMLMNAPMP22ALOX15CRBN | |
| Urea SCHEMBL2959932 | 0.85 | — | — | |
| Dimethyl Sulfone SCHEMBL21635409 | 0.85 | — | — | |
| Sulfuric Acid SCHEMBL11247873 | 0.85 | — | — | |
| Sulfuric Acid SCHEMBL27941813 | 0.83 | BLM (0.53) | BLMLMNAPMP22ALOX15CRBN | |
| Acetamide SCHEMBL27622549 | 0.81 | BLM (0.61) | BLMLMNAPMP22ALOX15CRBN | |
| Sulfamate SCHEMBL26965441 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541829-A | N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate | AICURIS GMBH & CO KG | 2016-05-04 | — | — | CN | claimed |
| CN-103842359-A | N- [5- (aminosulfonyl) -4-methyl-1, 3-thiazol-2-yl ] -N-methyl-2- [4- (2-pyridinyl) phenyl ] acetamide mesylate monohydrate | AICURIS GMBH & AMP | 2014-06-04 | — | — | CN | claimed |
| CN-103842360-B | N- [5- (aminosulfonyl) -4-methyl-1, 3-thiazol-2-yl ] -N-methyl-2- [4- (2-pyridinyl) phenyl ] acetamide mesylate monohydrate having a specific particle size distribution range and specific surface area range for use in pharmaceutical formulations | 艾库里斯有限责任两合公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-103842360-B | N- [5- (aminosulfonyl) -4-methyl-1, 3-thiazol-2-yl ] -N-methyl-2- [4- (2-pyridinyl) phenyl ] acetamide mesylate monohydrate having a specific particle size distribution range and specific surface area range for use in pharmaceutical formulations | 艾库里斯有限责任两合公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-103842359-B | N- [5- (aminosulfonyl) -4-methyl-1, 3-thiazol-2-yl ] -N-methyl-2- [4- (2-pyridinyl) phenyl ] acetamide mesylate monohydrate | AICURIS GMBH & CO.KG (DE) | 2016-05-25 | — | — | CN | disclosed |
| CN-105541829-A | N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate | AICURIS GMBH & CO KG | 2016-05-04 | — | — | CN | disclosed |
| CN-103842360-A | N- [5- (aminosulfonyl) -4-methyl-1, 3-thiazol-2-yl ] -N-methyl-2- [4- (2-pyridinyl) phenyl ] acetamide mesylate monohydrate having a specific particle size distribution range and specific surface area range for use in pharmaceutical formulations | AICURIS GMBH & CO KG | 2014-06-04 | — | — | CN | disclosed |
| CN-103842359-A | N- [5- (aminosulfonyl) -4-methyl-1, 3-thiazol-2-yl ] -N-methyl-2- [4- (2-pyridinyl) phenyl ] acetamide mesylate monohydrate | AICURIS GMBH & AMP | 2014-06-04 | — | — | CN | disclosed |