Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.59 |
| ▸ | NR2F2 | P24468 | 4/20 | 0.59 |
| ▸ | GALR3 | O60755 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | LDHA | P00338 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.54 |
| ▸ | ALPG | P10696 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10061697 | 0.91 | SMN1; SMN2 (0.67) | EGFRNR2F2GALR3RAB9ASMN1; SMN2 | |
| SCHEMBL12199178 | 0.78 | SMN1; SMN2 (0.77) | EGFRNR2F2GALR3RAB9ASMN1; SMN2 | |
| SCHEMBL13620923 | 0.77 | MAP4K4 (0.66) | EGFRLMNAMAPK1TSHRKMT2A | |
| SCHEMBL8422644 | 0.76 | EGFR (0.69) | EGFRNR2F2GALR3RAB9ASMN1; SMN2 | |
| SCHEMBL1084184 | 0.75 | CYP1A1 (0.77) | LMNAMAPK1KMT2AMEN1MAPT | |
| SCHEMBL883724 | 0.75 | EGFR (0.61) | EGFRNR2F2GALR3RAB9ASMN1; SMN2 | |
| SCHEMBL11258419 | 0.74 | LDHA (0.64) | EGFRNR2F2GALR3RAB9ASMN1; SMN2 | |
| SCHEMBL7612718 | 0.74 | EGFR (1.00) | EGFRNR2F2GALR3RAB9ASMN1; SMN2 | |
| SCHEMBL29386010 | 0.74 | EGFR (1.00) | EGFRNR2F2GALR3RAB9ASMN1; SMN2 | |
| SCHEMBL170193 | 0.74 | LMNA (0.97) | EGFRNR2F2GALR3RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103980209-B | A kind of 4-N-replaces-5-chloro-quinazoline compounds and preparation method and application | GUIZHOU UNIVERSITY (CN) | 2016-03-09 | — | — | CN | claimed |
| CN-103980209-A | 4-N-substituted-5-chloroquinazoline compound and preparation method and application thereof | UNIV GUIZHOU | 2014-08-13 | — | — | CN | claimed |
| CN-103980209-B | A kind of 4-N-replaces-5-chloro-quinazoline compounds and preparation method and application | GUIZHOU UNIVERSITY (CN) | 2016-03-09 | — | — | CN | disclosed |
| CN-103980209-A | 4-N-substituted-5-chloroquinazoline compound and preparation method and application thereof | UNIV GUIZHOU | 2014-08-13 | — | — | CN | disclosed |