Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185926 | 0.85 | HCAR2 (0.48) | LMNAHCAR2ELANEHSD17B10KMT2A | |
| SCHEMBL13134216 | 0.81 | KMT2A (0.46) | MAPTPOLBHCAR2ELANEHSD17B10 | |
| SCHEMBL6628850 | 0.79 | HCAR2 (0.42) | MAPTHCAR2HSD17B10ALDH1A1KMT2A | |
| SCHEMBL27950383 | 0.79 | HCAR2 (0.42) | HCAR2HSD17B10KMT2A | |
| SCHEMBL18917196 | 0.76 | KMT2A (0.44) | LMNAMAPTPOLBHCAR2HSD17B10 | |
| SCHEMBL701147 | 0.76 | LMNA (0.58) | LMNAMAPTPOLBPKMCYP3A4 | |
| Hydrochloric Acid SCHEMBL2327786 | 0.74 | LMNA (0.56) | LMNAMAPTPOLBPKMCYP3A4 | |
| Hydrochloric Acid SCHEMBL27539616 | 0.74 | LMNA (0.56) | LMNAMAPTPOLBPKMCYP3A4 | |
| SCHEMBL29655599 | 0.73 | KMT2A (0.58) | LMNAMAPTPKMCYP3A4ALDH1A1 | |
| SCHEMBL909511 | 0.73 | KMT2A (0.58) | LMNAMAPTPKMCYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109863151-A | Fused tricyclic pyridazinone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2019-06-07 | — | — | CN | claimed |
| CN-109863151-A | Fused tricyclic pyridazinone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-104822670-A | 5-phenoxy-3h-pyrimidin-4-one derivatives and their use as HIV reverse transcriptase inhibitors | MERCK SHARP & DOHME | 2015-08-05 | — | — | CN | disclosed |
| CN-103930406-A | 1-pyridazinyl-hydroxyimino- 3- phenyl- propanes as GPBAR1 agonists | HOFFMANN LA ROCHE | 2014-07-16 | — | — | CN | disclosed |