Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | TEC | P42680 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 7/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680404 | 0.91 | ROCK1 (0.36) | BTKFYNSRCTECITK | |
| SCHEMBL680953 | 0.71 | ROCK2 (0.44) | BTKFYNSRCTECITK | |
| SCHEMBL27691321 | 0.71 | RAF1 (0.46) | — | |
| SCHEMBL27691330 | 0.70 | MET (0.37) | — | |
| SCHEMBL680530 | 0.70 | MAPK14 (0.45) | MEN1KMT2AROCK1ROCK2KDM4E | |
| SCHEMBL27711608 | 0.70 | AXL (0.36) | FLT3 | |
| SCHEMBL16845710 | 0.70 | ROCK1 (0.47) | MEN1KMT2AROCK1ROCK2MAPT | |
| SCHEMBL680323 | 0.69 | TLR8 (0.44) | BTKFYNSRCTECITK | |
| SCHEMBL680692 | 0.69 | TLR8 (0.41) | BTKFYNSRCTECITK | |
| SCHEMBL27228043 | 0.69 | TRPA1 (0.41) | MEN1KMT2AROCK1ROCK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102105462-B | Amidophenoxyindazoles useful as inhibitors of C-MET | LILLY CO ELI | 2014-07-23 | — | — | CN | disclosed |