Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | QDPR | P09417 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27914131 | 0.84 | SIGMAR1 (0.57) | DRD2SIGMAR1MAPTMAPK1MEN1 | |
| SCHEMBL28096230 | 0.84 | SIGMAR1 (0.57) | DRD2KDM4ESIGMAR1MAPTLMNA | |
| SCHEMBL27801629 | 0.84 | KDM4E (0.56) | DRD4DRD2DRD3KDM4ESIGMAR1 | |
| SCHEMBL27979395 | 0.82 | MEN1 (0.42) | KDM4EQDPRSIGMAR1MAPTMAPK1 | |
| SCHEMBL14385616 | 0.82 | DRD4 (0.50) | DRD4DRD2DRD3KDM4EQDPR | |
| SCHEMBL28108120 | 0.80 | QDPR (0.51) | KDM4EQDPRSIGMAR1MAPTMEN1 | |
| SCHEMBL27945231 | 0.79 | KDM4E (0.41) | DRD4DRD2DRD3KDM4EQDPR | |
| SCHEMBL20582537 | 0.77 | PPARG (0.45) | KDM4ESIGMAR1MEN1KMT2A | |
| SCHEMBL28044690 | 0.77 | SIGMAR1 (0.47) | KDM4ESIGMAR1MAPTLMNAMEN1 | |
| SCHEMBL28042941 | 0.77 | KDM4E (0.38) | DRD4DRD2DRD3KDM4ESIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104684906-A | NAMPT inhibitors | ABBVIE INC | 2015-06-03 | — | — | CN | disclosed |
| CN-104428301-A | NAMPT inhibitors | ABBVIE INC | 2015-03-18 | — | — | CN | disclosed |