Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2947498 | 0.78 | PTK2B (0.51) | ALDH1A1HPGDSMN1; SMN2TP53MAPT | |
| SCHEMBL6753741 | 0.75 | ALDH1A1 (0.49) | ALDH1A1HPGDSMN1; SMN2TP53MAPT | |
| SCHEMBL3822896 | 0.74 | L3MBTL1 (0.41) | ALDH1A1HPGDSMN1; SMN2TP53MAPT | |
| SCHEMBL16463810 | 0.74 | TSHR (0.43) | ALDH1A1SMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL28018948 | 0.74 | KMT2A (0.52) | ALDH1A1SMN1; SMN2KMT2AMEN1AKR1C3 | |
| SCHEMBL28676328 | 0.70 | KMT2A (0.50) | ALDH1A1HPGDSMN1; SMN2TP53MAPT | |
| SCHEMBL4472090 | 0.69 | MAPT (0.55) | ALDH1A1HPGDSMN1; SMN2TP53MAPT | |
| SCHEMBL5790498 | 0.68 | MAPT (0.46) | ALDH1A1HPGDSMN1; SMN2TP53MAPT | |
| SCHEMBL28018403 | 0.68 | LIPE (0.48) | ALDH1A1HPGDSMN1; SMN2KMT2AAKR1C3 | |
| SCHEMBL226315 | 0.67 | KMT2A (0.55) | ALDH1A1HPGDSMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104080777-B | Morpholinyl derivatives as MOGAT-2 inhibitors | ELI LILLY AND CO. (US) | 2015-12-09 | — | — | CN | disclosed |
| CN-104080777-A | Morpholinyl derivatives as MOGAT-2 inhibitors | LILLY CO ELI | 2014-10-01 | — | — | CN | disclosed |