Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28110444 | 0.98 | KDM4E (0.43) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL2631222 | 0.88 | MAPT (0.42) | KDM4EALDH1A1MAPTHPGDTSHR | |
| Hydrochloric Acid SCHEMBL16468136 | 0.86 | KDM4E (0.41) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL25514677 | 0.80 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL27972517 | 0.76 | BCAT2 (0.49) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL27985191 | 0.74 | LMNA (0.50) | KDM4EALDH1A1MAPTTSHRHSD17B10 | |
| SCHEMBL3261493 | 0.72 | PLA2G2A (0.34) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL3458337 | 0.72 | JAK2 (0.46) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL20305412 | 0.71 | CLK1 (0.43) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL1420264 | 0.71 | MKNK1 (0.47) | KDM4EALDH1A1MAPTHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104066330-A | Isoxazoline derivatives for controlling ectoparasites | LILLY CO ELI | 2014-09-24 | — | — | CN | claimed |
| US-20250368646-A1 | TRICYCLIC FUSED WRN INHIBITORS | NIMBUS WADJET INC (US) | 2025-12-04 | — | — | US | disclosed |
| CN-110381738-A | Pesticide and Parasiticidal vinyl isoxazoline compound | 勃林格殷格翰动物保健美国公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-105906655-A | Isoxazoline derivatives used in the control of ectoparasites | 安纳考尔医药公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-104066330-B | Isoxazoline derivatives for controlling ectoparasites | ANACOR PHARMACEUTICALS, INC. (US) | 2016-05-18 | — | — | CN | disclosed |
| CN-104066330-A | Isoxazoline derivatives for controlling ectoparasites | LILLY CO ELI | 2014-09-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250368646-A1 | TRICYCLIC FUSED WRN INHIBITORS | WRN, BLM, RECQL | KDM4E 3402/4885ALDH1A1 3214/4885MAPT 3625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.