Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8074581 | 0.71 | HTR6 (0.65) | KDM4EALDH1A1HTR6 | |
| SCHEMBL14274543 | 0.70 | ADORA1 (0.51) | IKBKBCHUKAURKBDYRK1AALDH1A1 | |
| SCHEMBL28040158 | 0.70 | EGFR (0.53) | IKBKBCHUKEGFRAURKBMET | |
| SCHEMBL28110985 | 0.70 | CYP1A2 (0.48) | DYRK1AHTR6JAK2TTK | |
| SCHEMBL5270336 | 0.70 | MET (0.46) | IKBKBCHUKEGFRAURKBKDM4E | |
| SCHEMBL12613146 | 0.69 | IKBKB (0.36) | IKBKBCHUKEGFRAURKBDYRK1A | |
| SCHEMBL164638 | 0.69 | IKBKB (0.37) | IKBKBCHUKKDM4EMAPTJAK2 | |
| SCHEMBL1057965 | 0.68 | HRH4 (0.51) | IKBKBCHUKAURKBDYRK1AJAK2 | |
| SCHEMBL17113643 | 0.67 | MAPT (0.42) | IKBKBCHUKKDM4EALDH1A1MAPT | |
| SCHEMBL28111579 | 0.67 | TTK (0.39) | IKBKBCHUKAURKBDYRK1AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104817561-A | Piperidine inhibitors of Janus Kinase 3 | AUSPEX PHARMACEUTICALS LLC | 2015-08-05 | — | — | CN | disclosed |
| CN-102459270-B | Piperidine inhibitors of janus kinase 3 | AUSPEX PHARMACEUTICALS LLC | 2015-04-29 | — | — | CN | disclosed |
| CN-102459270-A | Piperidine inhibitors of janus kinase 3 | AUSPEX PHARMACEUTICALS LLC | 2012-05-16 | — | — | CN | disclosed |