SCHEMBL28006554

SCHEMBL28006554

CCCn1ncc(NC(=O)OC(C)(C)C)n1

nearest known ligand 0.45

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.45
DYRK1A Q13627 1/20 0.45
CACNA1H O95180 14/20 0.40
CYP17A1 P05093 2/20 0.39
CNR2 P34972 1/20 0.38
MAPK14 Q16539 1/20 0.37
BRD9 Q9H8M2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30899668 0.73 GSK3B (0.44) GSK3BDYRK1ACACNA1HCYP17A1CNR2
SCHEMBL30899677 0.71 GSK3B (0.40) GSK3BDYRK1A
SCHEMBL13472107 0.70 SMN1; SMN2 (0.54) GSK3BDYRK1ACYP17A1MAPK14
SCHEMBL28055517 0.70 RAF1 (0.49) GSK3BDYRK1ACACNA1HCYP17A1MAPK14
SCHEMBL18138249 0.69 CNR2 (0.35) GSK3BDYRK1ACYP17A1CNR2MAPK14
SCHEMBL25833918 0.69 CNR2 (0.38) GSK3BDYRK1ACYP17A1CNR2BRD9
SCHEMBL27032768 0.69 ALDH1A1 (0.41)
SCHEMBL12050053 0.69 ALDH1A1 (0.55) GSK3BDYRK1AMAPK14BRD9
SCHEMBL20885944 0.69 MAPK14 (0.42) GSK3BDYRK1ACYP17A1CNR2MAPK14
SCHEMBL23766172 0.69 TDP1 (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104370833-A Preparation method of 1,4-disubstituted triazole derivative Hunan huateng pharmaceutical co ltd 2015-02-25 CN disclosed