Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18138237 | 0.90 | RORC (0.37) | GSK3BDYRK1APTGDR2MAPK14HDAC3 | |
| SCHEMBL18138239 | 0.82 | DRD2 (0.39) | GSK3BDYRK1APTGDR2HDAC3HDAC8 | |
| SCHEMBL18138297 | 0.77 | GSK3B (0.33) | GSK3BDYRK1APTGDR2HDAC3HDAC8 | |
| SCHEMBL24896677 | 0.72 | L3MBTL1 (0.46) | CNR2MAPK14HDAC3HDAC8NCOR2 | |
| SCHEMBL27457664 | 0.69 | GSK3B (0.37) | CNR2GSK3BDYRK1APTGDR2MAPK14 | |
| SCHEMBL28006554 | 0.69 | GSK3B (0.45) | CNR2GSK3BDYRK1AMAPK14CYP17A1 | |
| SCHEMBL18138248 | 0.69 | L3MBTL1 (0.46) | L3MBTL1NPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL15885557 | 0.69 | NPSR1 (0.54) | GSK3BDYRK1APTGDR2MAPK14L3MBTL1 | |
| SCHEMBL19026780 | 0.69 | RAB9A (0.36) | CYP17A1NPC1RAB9ARECQLSMN1; SMN2 | |
| SCHEMBL18138351 | 0.68 | PRMT1 (0.36) | PTGDR2MAPK14L3MBTL1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164754-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |